The roles of ATF2 (activating transcription factor 2) in tumorigenesis
The roles of ATF2 (activating transcription factor 2) in tumorigenesis
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DOI：
10.1042/bst20110630
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发表时间：
2012-02-01
影响因子：
3.9
通讯作者：
Breitwieser, Wolfgang
中科院分区：
文献类型：
--
作者：
Gozdecka, Malgorzata;Breitwieser, Wolfgang
MAPK（丝裂原活化蛋白激酶）途径是癌症中最常见的失调信号事件之一。MAPK活性的关键靶标是AP-1（激活蛋白1）转录因子的成员，AP-1转录因子是由Jun、Fos、Maf和ATF（激活转录因子）家族DNA结合蛋白组成的二聚体复合物。取决于细胞环境，二聚体复合物的组成决定生长、存活或凋亡的调节。JNK（c-Jun N-末端激酶），p38和一些Jun和Fos家族蛋白已被分析为它们参与致癌转化和肿瘤形成。AP-1因子的ATF成分也出现了这些数据。本综述的目的是提供两个ATF家族蛋白，ATF 2和ATF 7，在哺乳动物的发育和肿瘤形成中的潜在功能的功能的概述。
MAPK (mitogen-activated protein kinase) pathways are among the most frequently deregulated signalling events in cancer. Among the critical targets of MAPK activities are members of the AP-1 (activator protein 1) transcription factor, a dimeric complex consisting of Jun, Fos, Maf and ATF (activating transcription factor) family DNA-binding proteins. Depending on the cellular context, the composition of the dimeric complexes determines the regulation of growth, survival or apoptosis. JNK (c-Jun N-terminal kinase), p38 and a number of Jun and Fos family proteins have been analysed for their involvement in oncogenic transformation and tumour formation. These data are also emerging for the ATF components of the AP-1 factor. The aim of the present review is to provide an overview of the functions of two ATF family proteins, ATF2 and ATF7, in mammalian development and their potential functions in tumour formation.