Vesicle Formation and Microphase Behavior of Amphiphilic ABC Triblock Copolymers in Selective Solvents: A Monte Carlo Study
Vesicle Formation and Microphase Behavior of Amphiphilic ABC Triblock Copolymers in Selective Solvents: A Monte Carlo Study
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两亲性 ABC 三嵌段共聚物在选择性溶剂中的囊泡形成和微相行为：蒙特卡罗研究
DOI：
10.1021/la102211d
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发表时间：
2010-08-17
期刊：
影响因子：
3.9
通讯作者：
Jiang, Wei
中科院分区：
文献类型：
--
作者：
Cui, Jie;Jiang, Wei
采用蒙特卡罗模拟方法，研究了ABC三嵌段共聚物在A、C嵌段选择性溶剂中的囊泡形成和微相行为。模拟结果表明，嵌段A和C的亲水性不仅决定了微泡的形成，而且决定了微相的行为。如果A块和C块长度相等，则A块(亲水性较低)可能聚集在内表面，而C块(亲水性较高)倾向于向外表面移动，形成ABC(从内到外)三层囊泡。模拟结果表明，如果两嵌段之间的亲水性差足够小，则在膜闭合后(即在囊泡轮廓形成后)形成ABC三层。否则，在膜关闭之前形成ABC三层。此外，本文还研究和讨论了两亲嵌段(A和C)之间的链长和不相容的影响。较短的嵌段A更有可能在内表面聚集，A和C之间的不相容性必须足够强，以确保ABC共聚物形成ABC(从内到外)三层囊泡。
Using Monte Carlo simulation, we studied the vesicle formation and microphase behavior of ABC triblock copolymers in selective solvent for A and C blocks. Simulation results show that the hydrophilicity of Blocks A and C determines not only the vesicle formation but also the microphase behavior. If Blocks A and C are of equal length, then Block A (with lower hydrophilicity) is likely to aggregate on the inner surface, whereas Block C (with higher hydrophilicity) tends to move to the outer surface, forming the ABC (from inside to outside) three-layer vesicle. Simulation results reveal that if the hydrophilicity difference between the two blocks is sufficiently low, then the ABC three layers are formed after the membrane closes (i.e., after the formation of vesicle profile). Otherwise, the ABC three layers are formed before the membrane closes. Furthermore, the effect of chain length and incompatibility between the two amphiphilic blocks (i.e., A and C) is studied and discussed in this article. The shorter block A is much more likely to aggregate on the inner surface, and the incompatibility between A and C must be sufficiently strong to ensure that the ABC copolymer forms an ABC (from inside to outside) three-layer vesicle.