Immunohistochemical study of carcinoembryonic antigen in patients with colorectal cancer. Correlation with plasma carcinoembryonic antigen levels
Immunohistochemical study of carcinoembryonic antigen in patients with colorectal cancer. Correlation with plasma carcinoembryonic antigen levels
复制标题
结直肠癌患者癌胚抗原的免疫组织化学研究。
作者：
Y. Hamada;M. Yamamura;Kohshiro Hioki;M. Yamamoto;H. Nagura;Keiichi Watanabe
使用过氧化物酶-抗过氧化物酶（PAP）方法，在常规处理的结直肠癌组织中显示癌胚抗原（CEA）。本文提出了一种新的基于定位方式的结直肠癌免疫组化分级方法，旨在阐明结直肠癌患者血浆CEA水平升高的原因。大多数分化良好的腺癌患者，其中CEA沿癌细胞的顶面沿着密集分布，但沿基底面沿着很少存在，血浆CEA水平非常低，而所有显示CEA分布在间质中以及癌细胞的整个表面及其细胞质上的患者显示高血浆CEA水平。此外，血管和淋巴管浸润的分级和存在之间有很好的相关性。因此，由于癌细胞基底外侧质膜上CEA的异常分布，周围间质中CEA的出现可能在结直肠癌患者血浆CEA水平升高中起重要作用。
Using peroxidase‐antiperoxidase (PAP) method, carcinoembryonic antigen (CEA) was demonstrated in conventionally processed colorectal cancer tissues. A new immunohistochemical grading for colorectal cancers based on the mode of the localization was made in an attempt to clarify the factors responsible for elevation of plasma CEA levels in colorectal cancer patients. Most of the patients with well differentiated adenocarcinoma, in which CEA was densely distributed along the apical surface but only rarely present along the basolateral surfaces of the carcinoma cells, had very low levels of plasma CEA, whereas all patients showing CEA distribution in the stroma as well as over the entire surfaces of the cancer cells and their cytoplasm showed high plasma CEA levels. In addition, there was a good correlation between the grading and presence of the blood vessel and lymphatic invasions. Thus, the appearance of CEA in the surrounding stroma, due to abnormal distribution of CEA on the basolateral plasma membrane of cancer cells, may play a significant role in the elevation of plasma CEA levels in colorectal cancer patients.
肿瘤标志物在结直肠癌治疗中的作用。
影响因子：
6.2
作者：
Go,VL;Zamcheck,N
通讯作者：
Zamcheck,N