Functional imaging of the monkey brain
Functional imaging of the monkey brain
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DOI：
10.1038/9210
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发表时间：
1999-06-01
影响因子：
25
通讯作者：
Pauls, J
中科院分区：
文献类型：
--
作者：
Logothetis, NK;Guggenberger, H;Pauls, J
功能性磁共振成像（fMRI）已成为研究人类大脑功能的重要工具。在此我们描述该技术在麻醉猴子身上的应用。我们呈现了基于血氧水平依赖（BOLD）对比的猴子大脑皮层的空间分辨功能图像。在4.7特斯拉的磁场中，使用优化的多层、梯度回波、回波平面成像（EPI）序列对整个大脑进行成像，利用棋盘格图案或灵长类动物图片来研究视觉皮层的刺激诱导激活。在我们的麻醉方案下，视觉刺激使外侧膝状体核（LGN）、初级视觉区（V1）以及一些纹外视觉区（包括颞上沟区域）产生了强烈、可重复的局部激活。在执行辨别任务的清醒、有行为表现的猴子身上也获得了类似的反应。
Functional magnetic resonance imaging (fMRI) has become an essential tool for studying human brain function. Here we describe the application of this technique to anesthetized monkeys. We present spatially resolved functional images of the monkey cortex based on blood oxygenation level dependent (BOLD) contrast. Checkerboard patterns or pictures of primates were used to study stimulus-induced activation of the visual cortex, in a 4.7-Tesla magnetic field, using optimized multi-slice, gradient-recalled, echo-planar imaging (EPI) sequences to image the entire brain. Under our anesthesia protocol, visual stimulation yielded robust, reproducible, focal activation of the lateral geniculate nucleus (LGN), the primary visual area (V1) and a number of extrastriate visual areas, including areas in the superior temporal sulcus. Similar responses were obtained in alert, behaving monkeys performing a discrimination task.