In vivo cardiac phase response curve elucidates human respiratory heart rate variability
In vivo cardiac phase response curve elucidates human respiratory heart rate variability
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DOI：
10.1038/ncomms3418
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发表时间：
2013-09-01
影响因子：
16.6
通讯作者：
Moser, Maximilian
中科院分区：
文献类型：
--
作者：
Kralemann, Bjoern;Fruehwirth, Matthias;Moser, Maximilian
从观察中恢复内源性节律的相互作用是具有挑战性的，特别是如果解释系统行为的数学模型是未知的。成功重建动态特性的决定性信息是振荡器对外部影响的灵敏度，这通过其相位响应曲线来量化。在这里，我们提出了一种技术，允许提取的相位响应曲线从一个非侵入性的观察组成的系统，在这种情况下，心跳和呼吸，在其自然环境中，并在自由运行的条件下。我们使用这种方法来获得相位耦合功能描述心肺相互作用和相位响应曲线的17个健康人。我们第一次显示的阶段，在该阶段的心脏跳动是容易受到呼吸驱动和提取的心率变异性的相关组成部分。这种非侵入性的方法，用于耦合振荡器的相位响应曲线的测定可以在许多科学学科中找到应用。
Recovering interaction of endogenous rhythms from observations is challenging, especially if a mathematical model explaining the behaviour of the system is unknown. The decisive information for successful reconstruction of the dynamics is the sensitivity of an oscillator to external influences, which is quantified by its phase response curve. Here we present a technique that allows the extraction of the phase response curve from a non-invasive observation of a system consisting of two interacting oscillators-in this case heartbeat and respiration-in its natural environment and under free-running conditions. We use this method to obtain the phase-coupling functions describing cardiorespiratory interactions and the phase response curve of 17 healthy humans. We show for the first time the phase at which the cardiac beat is susceptible to respiratory drive and extract the respiratory-related component of heart rate variability. This non-invasive method for the determination of phase response curves of coupled oscillators may find application in many scientific disciplines.