Botulinum Toxin-A Dosing Trends for Adductor Spasmodic Dysphonia at a Single Institution Over 10 Years
Botulinum Toxin-A Dosing Trends for Adductor Spasmodic Dysphonia at a Single Institution Over 10 Years
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DOI：
10.1016/j.jvoice.2016.09.022
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发表时间：
2017-05-01
期刊：
影响因子：
2.2
通讯作者：
Johns, Michael M., III
中科院分区：
文献类型：
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作者：
Bradley, Joseph P.;Barrow, Emily M.;Johns, Michael M., III
目标。本研究旨在确定A型肉毒毒素治疗内收肌痉挛发音困难(ADSD)的剂量在长期内的变化。研究设计。这是一篇回顾图表。方法。从临床数据库中确定了2003年至2013年期间接受ADSD治疗的113名受试者。所有至少注射10次的受试者的年龄、性别和总注射剂量都被记录下来。54名受试者符合纳入标准。受试者的起始剂量没有年龄或性别差异。剂量较第二针(5.05+/-1.623单位)、第六针(4.26+/-1.698单位)显著减少，并持续到第十针(4.08+/-2.019单位)(P<；0.005)。肉毒杆菌毒素-在最初的两次剂量滴定后，ADSD的A剂量在随后的注射中持续减少。
Objectives. This study aimed to identify the changes in dosing of botulinum toxin-A for adductor spasmodic dysphonia (ADSD) over a prolonged period. Study Design. This is a retrospective chart review.Methods. One hundred thirteen subjects treated for ADSD from 2003 to 2013 were identified from a clinical database. Subject age, gender, and total injection dose amount were all recorded for all subjects who had at least 10 injections.Results. Fifty-four subjects met criteria for inclusion. There were no age or gender differences in the starting dose for subjects. Dosing decreased significantly compared with the second dose (5.05 +/- 1.623 Units), by the sixth dose (4.26 +/- 1.698 Units), and continued through the 10th dose (4.08 +/- 2.019 Units) (P < 0.005 for all).Conclusions. Botulinum toxin-A dosing for ADSD decreases consistently over subsequent injections after the initial two dose titrations.