A Conformable and Tough Janus Adhesive Patch with Limited 1D Swelling Behavior for Internal Bioadhesion
A Conformable and Tough Janus Adhesive Patch with Limited 1D Swelling Behavior for Internal Bioadhesion
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DOI：
10.1002/adfm.202303836
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发表时间：
2023-06
影响因子：
19
通讯作者：
Kai Chen;Chenyu Liu;Jinghuan Huang;Lingbin Che;Yuan Yuan-Yuan;Changsheng Liu
中科院分区：
文献类型：
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作者：
Kai Chen;Chenyu Liu;Jinghuan Huang;Lingbin Che;Yuan Yuan-Yuan;Changsheng Liu
先进的生物粘附技术为挽救生命的内部外科手术提供了前所未有的机会。然而，大多数现有的生物粘合剂未能在体液丰富且不可避免的动态内环境中快速建立持久可靠的生物界面并有效重建正常的生理功能。在本文中，通过将物理交联的胍基化PEGS（PEGSG）和丙烯酰化PEGS-化学交联的聚（丙烯酸）-N-氢化琥珀酰亚胺酯（PEGSA-交联的PAAc-NHS）与单面两性离子聚合物互穿层整合，开发了基于聚乙二醇化聚（癸二酸甘油酯）的Janus粘合贴剂（基于PEGS的JAP）。干燥的JAP可以迅速吸收令人不快的界面水，并有效地与湿组织形成强烈的物理相互作用。受益于PEGSG的两亲性和简单的空间受限干燥过程，JAP能够抵抗过度溶胀，并沿沿着有限溶胀，以避免所建立的贴合贴片-组织界面劣化。此外，随后形成的共价相互作用可以进一步提高粘合强度并确保持久可靠的粘合。同时，由于物理交联网络的高效能量耗散机制，缺口不敏感和耐穿刺的JAP可以实现坚韧的粘附，以适应动态条件。结合上述理想特征和理想的术后抗粘连能力，基于PEGS的JAP被证明是内部组织粘连和功能重建的有希望的候选物。
Advanced bioadhesion techniques have offered unprecedented opportunities for life‐saving internal surgical procedures. However, most existing bioadhesives failed to rapidly establish long‐lasting reliable biointerface and effectively reconstruct normal physiological function in the body fluid‐rich and inevitable dynamic internal environment. Herein, a PEGylated poly(glycerol sebacate)‐based Janus adhesive patch (PEGS‐based JAP) is developed by integrating physically crosslinked guanidinylated PEGS (PEGSG) and acryloylated PEGS‐chemically crosslinked poly(acrylic acid)‐N‐hydrosuccinimide ester (PEGSA‐crosslinked PAAc‐NHS) with a single‐sided zwitterionic polymer‐interpenetrated layer. The dry JAP can rapidly absorb the unpleasant interfacial water and effectively form strong physical interactions with wet tissues. Benefiting from the amphiphilic nature of PEGSG and a simple spatial‐confined drying process, the JAP is allowed to resist excessive swelling and limitedly swell along one direction to avoid deterioration of the as‐established conformable patch‐tissue interface. Moreover, covalent interactions formed subsequently can further improve the adhesive strength and ensure a long‐lasting reliable adhesion. Meanwhile, the notch‐insensitive and puncture‐resistant JAP can achieve tough adhesion to adapt to the dynamic conditions owing to the highly efficient energy‐dissipation mechanism of the physically cross‐linked network. Combining the above ideal features with the desirable postoperative anti‐adhesion ability, the PEGS‐based JAP is demonstrated to be a promising candidate for internal tissue adhesion and function reconstruction.