The Jo-1 antibody system in myositis: relationships to clinical features and HLA.
The Jo-1 antibody system in myositis: relationships to clinical features and HLA.
复制标题
肌炎中的 Jo-1 抗体系统：与临床特征和 HLA 的关系。
作者：
F. Arnett;Hirsch Tj;Wilma B. Bias;M. Nishikai;M. Reichlin
在11/47例（23%）肌炎患者和0/35例系统性红斑狼疮或进行性系统性硬化症对照患者中发现了抗Jo-1（一种盐水可提取的核抗原）的抗体（p ≤ 0.01）。在肌炎亚组中，抗Jo-1发生在6/20（30%）多发性肌炎，2/16（13%）皮肌炎和3/7（43%）重叠。无论种族或临床亚组如何，Jo-1抗体与HLA-DR 3之间存在关联（p小于或等于0.05）。所有抗-Jo-1阳性患者具有HLA-DR 3、HLA-DRW 6或两者（p小于或等于0.01）。因此，这种抗体系统可能是由于肌炎患者在HLA-D处或附近介导的异常免疫应答而产生的。
Antibodies to Jo-1, a saline extractable nuclear antigen, were found in 11/47 (23%) patients with myositis and in 0/35 controls with systemic lupus erythematosus or progressive systemic sclerosis (p less than or equal to 0.01). Within myositis subgroups, anti-Jo-1 occurred in 6/20 (30%) with polymyositis, 2/16 (13%) with dermatomyositis and 3/7 (43%) with overlap. There was an association between Jo-1 antibodies and HLA-DR3, irrespective of race or clinical subgroups (p less than or equal to 0.05). All anti-Jo-1 positive patients had either HLA-DR3, HLA-DRW6 or both (p less than or equal to 0.01). Thus, this antibody system might arise as a result of an aberrant immune response mediated at or near HLA-D in patients with myositis.