Heart failure and atrial fibrillation: new concepts in pathophysiology, management, and future directions
Heart failure and atrial fibrillation: new concepts in pathophysiology, management, and future directions
复制标题
DOI：
10.1007/s10741-021-10133-6
复制
发表时间：
2021-07-04
影响因子：
4.6
通讯作者：
Davlouros, Periklis
中科院分区：
文献类型：
--
作者：
Tsigkas, Grigorios;Apostolos, Anastasios;Davlouros, Periklis
心衰和房颤之间存在着双向的病理生理联系，形成了一种频繁且具有挑战性的共病，包括神经激素过度激活、纤维化发展和电生理重构，同时它们具有共同的危险因素。对这些破坏性合并症的管理包括大多数针对心力衰竭的既定治疗措施，以及心律或心率控制和抗凝治疗（主要针对心房颤动），这可以通过药物或非药物方法实现。目前的手稿旨在回顾现有的文献关于潜在的病理生理，提出新的治疗趋势，并预测这两种相关疾病的未来前景与众多悬而未决的问题。
A bidirectional pathophysiological link connects heart failure and atrial fibrillation, creating a frequent and challenging comorbidity, which includes neurohormonal hyperactivation, fibrosis development, and electrophysiologic remodeling, while they share mutual risk factors. Management for these devastating comorbidities includes most of the established treatment measures for heart failure as well as rhythm or rate control and anticoagulation mostly for atrial fibrillation, which can be achieved with either pharmaceutical or non-pharmaceutical approaches. The current manuscript aims to review the existing literature regarding the underlying pathophysiology, to present the novel trends of treatment, and to predict the future perspective of these two linked diseases with the numerous unanswered questions.