Modulation of Cardiac Potassium Current by Neural Tone and Ischemia.
Modulation of Cardiac Potassium Current by Neural Tone and Ischemia.
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DOI：
10.1016/j.ccep.2016.01.007
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发表时间：
2016-06
影响因子：
--
通讯作者：
Arora R
中科院分区：
文献类型：
--
作者：
Tomson TT;Arora R
The cardiac action potential is generated by intricate flows of ions across myocyte cell membranes in a coordinated fashion to control myocardial contraction and the heart rhythm. Modulation of the flow of these ions in response to a variety of stimuli results in changes to the action potential. Abnormal or altered ion currents can result in cardiac arrhythmias. Potassium currents are particularly important for determining the cardiac action potential duration and repolarization. The autonomic nervous system plays an important role in the modulation of cardiac electrophysiology and has a particularly important role in modulation of potassium currents. Abnormalities of autonomic regulation of potassium current play a role in the genesis of cardiac arrhythmias, and alterations in acetylcholine-activated potassium channels may play a key role in atrial fibrillation. Ischemia is another important modulator of cardiac cellular electrophysiology that alters cardiac potassium current through effects on ATP-sensitive potassium channels in ways that may result in cardiac arrhythmias, particularly ventricular fibrillation.
