Post-COVID-19 persistent headache: A multicentric 9-months follow-up study of 905 patients
Post-COVID-19 persistent headache: A multicentric 9-months follow-up study of 905 patients
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DOI：
10.1177/03331024211068074
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发表时间：
2022-02-15
期刊：
影响因子：
4.9
通讯作者：
Pozo-Rosich, Patricia
中科院分区：
文献类型：
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作者：
Garcia-Azorin, David;Layos-Romero, Almudena;Pozo-Rosich, Patricia
背景 头痛是 2019 年冠状病毒病 (COVID-19) 的常见症状。其长期演变仍然未知。我们的目的是评估在 COVID-19 急性期出现头痛的患者头痛的长期持续时间。方法这是一项事后多中心双向研究，纳入2020年3月1日至4月27日期间来自六家不同三级医院的患者。患者完成了9个月的神经系统随访。结果 我们纳入了 905 名患者。他们的中位年龄为 51 岁（IQR 45-65），66.5% 为女性，52.7% 有原发性头痛病史。头痛的中位持续时间为 14 (6-39) 天；然而，头痛在 3 个月后持续存在的比例为 19.0%（95% CI：16.5-21.8%），9 个月后的比例为 16.0%（95% 置信区间：13.7-18.7%）。急性期的头痛强度与头痛持续时间较长相关（风险比 0.655；95% 置信区间：0.582-0.737）。结论 头痛的中位持续时间为 2 周，但大约五分之一的患者头痛持续且呈慢性日常模式。
Background Headache is a frequent symptoms of coronavirus disease 2019 (COVID-19). Its long-term evolution remains unknown. We aim to evaluate the long-term duration of headache in patients that presented headache during the acute phase of COVID-19. Methods This is a post-hoc multicenter ambisective study including patients from six different third-level hospitals between 1 March and 27 April 2020. Patients completed 9 months of neurological follow-up. Results We included 905 patients. Their median age was 51 (IQR 45-65), 66.5% were female, and 52.7% had a prior history of primary headache. The median duration of headache was 14 (6-39) days; however, the headache persisted after 3 months in 19.0% (95% CI: 16.5-21.8%) and after 9 months in 16.0% (95% confidence interval: 13.7-18.7%). Headache intensity during the acute phase was associated with a more prolonged duration of headache (Hazard ratio 0.655; 95% confidence interval: 0.582-0.737). Conclusion The median duration of headache was 2 weeks, but in approximately a fifth of patients it became persistent and followed a chronic daily pattern.