WildCARDs: inflammatory caspases directly detect LPS.
WildCARDs: inflammatory caspases directly detect LPS.
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WildCARD：炎症半胱天冬酶直接检测 LPS。
DOI：
10.1038/cr.2014.128
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发表时间：
2015
期刊：
影响因子：
44.1
通讯作者：
Miao,EdwardAxel
中科院分区：
文献类型：
--
作者：
Hagar,JonAlan;Aachoui,Youssef;Miao,EdwardAxel
炎症性半胱天冬酶（其中包括 caspase-1、鼠 caspase-11 以及人 caspase-4 和 5（鼠 caspase-11 的同源物））对于剥夺感染因子的细胞内复制生态位至关重要。在对给定的刺激做出反应后，它们变得具有催化活性并引发一种称为细胞焦亡的程序性炎症细胞死亡。通过检查它们在人类和其他哺乳动物中的同源性和相邻染色体排列，很明显，炎症性 caspase 源自一系列基因复制和随后的分歧。平衡的 caspase-1 反应对于防御多种感染因子至关重要，而其异常激活是许多免疫病理的基础。关于感染中的 caspase-11、-4 和-5 知之甚少；然而，我们已经证明 caspase-11 的一个生理作用是检测并帮助清除细胞质侵入性感染，例如由泰国伯克霍尔德杆菌引起的感染 [1]。最近的研究表明，caspase-11 介导对 DSS 诱导的结肠炎的抵抗力 [2]，并清除肠道沙门氏菌血清型鼠伤寒感染的细胞。
The inflammatory caspases—among them caspase-1, murine caspase-11, and human caspase-4 and-5 (homologs of murine caspase-11)—are central to depriving infectious agents of intracellular replication niches. Upon responding to a given stimulus, they become catalytically active and initiate a form of programmed inflammatory cell death termed pyroptosis. By examining their homology and adjacent chromosomal arrangement in humans and other mammals, it is apparent that the inflammatory caspases originate from a series of gene duplications and subsequent divergences.A balanced caspase-1 response is critical to defense against a variety of infectious agents, whereas its aberrant activation underlies a number of immune pathologies. Less is known about caspase-11,-4, and-5 in infection; however, we have shown that one physiological role of caspase-11 is to detect and help clear cytosol invasive infections, such as those caused by Burkholderia thailandensis [1]. More recent work has shown that caspase-11 mediates resistance to DSS-induced colitis [2] and clearance of Salmonella enterica serovar Typhimurium-infected cells in