Use of a risk scoring tool to identify higher-risk HIV-1 serodiscordant couples for an antiretroviral-based HIV-1 prevention intervention.
Use of a risk scoring tool to identify higher-risk HIV-1 serodiscordant couples for an antiretroviral-based HIV-1 prevention intervention.
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DOI：
10.1186/s12879-016-1899-y
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发表时间：
2016-10-17
影响因子：
3.7
通讯作者：
Partners Demonstration Project Team
中科院分区：
文献类型：
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作者：
Irungu EM;Heffron R;Mugo N;Ngure K;Katabira E;Bulya N;Bukusi E;Odoyo J;Asiimwe S;Tindimwebwa E;Celum C;Baeten JM;Partners Demonstration Project Team
Antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) reduce HIV-1 transmission within heterosexual HIV-1 serodiscordant couples. Prioritizing couples at highest HIV-1 transmission risk for ART and PrEP would maximize impact and minimize costs. The Partners Demonstration Project is an open-label, delivery study of integrated PrEP and ART for HIV-1 prevention among high risk HIV-1 serodiscordant couples in Kenya and Uganda. We evaluated the feasibility of using a validated risk score that weighs a combination of easily measurable factors (age, children, marital status, male circumcision status, condom use, plasma HIV-1 levels) to identify couples at highest risk for HIV-1 transmission for enrollment. Couples scoring ≥5 met the risk score eligibility criteria. We screened 1694 HIV-1 serodiscordant couples and enrolled 1013. Of the screened couples, 1331 (78.6 %) scored ≥5 (with an expected incidence >3 % per year) and 76 % of these entered the study. The median age of the HIV-1 uninfected partner was 29 years [IQR 26, 36] and 20 % were <25 years of age. The HIV-1 uninfected partner was male in 67 % of partnerships, 33 % of whom were uncircumcised, 57 % of couples had no children, and 65 % reported unprotected sex in the month prior to enrollment. Among HIV-1 infected partners, 41 % had plasma viral load >50,000 copies/ml. A risk scoring tool identified HIV-1 serodiscordant couples for a demonstration project of PrEP and ART with high HIV-1 risk. The tool may be feasible for research and public health settings to maximize efficiency and minimize HIV-1 prevention costs.
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影响因子：
16.1
作者：
Barnabas, Ruanne V.;van Rooyen, Heidi;Tumwesigye, Elioda;Murnane, Pamela M.;Baeten, Jared M.;Humphries, Hilton;Turyamureeba, Bosco;Joseph, Philip;Krows, Meighan;Hughes, James P.;Celum, Connie
通讯作者：
Celum, Connie
DOI：
10.1097/qai.0000000000000192
发表时间：
2014-08-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Mujugira A;Celum C;Thomas KK;Farquhar C;Mugo N;Katabira E;Bukusi EA;Tumwesigye E;Baeten JM;Partners PrEP Study Team
通讯作者：
Partners PrEP Study Team
DOI：
10.1056/nejmoa1108524
发表时间：
2012-08-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baeten JM;Donnell D;Ndase P;Mugo NR;Campbell JD;Wangisi J;Tappero JW;Bukusi EA;Cohen CR;Katabira E;Ronald A;Tumwesigye E;Were E;Fife KH;Kiarie J;Farquhar C;John-Stewart G;Kakia A;Odoyo J;Mucunguzi A;Nakku-Joloba E;Twesigye R;Ngure K;Apaka C;Tamooh H;Gabona F;Mujugira A;Panteleeff D;Thomas KK;Kidoguchi L;Krows M;Revall J;Morrison S;Haugen H;Emmanuel-Ogier M;Ondrejcek L;Coombs RW;Frenkel L;Hendrix C;Bumpus NN;Bangsberg D;Haberer JE;Stevens WS;Lingappa JR;Celum C;Partners PrEP Study Team
通讯作者：
Partners PrEP Study Team
影响因子：
3.8
作者：
Cremin, Ide;Hallett, Timothy B.
通讯作者：
Hallett, Timothy B.
影响因子：
16.1
作者：
Genberg, Becky L.;Naanyu, Violet;Braitstein, Paula
通讯作者：
Braitstein, Paula