Epigenomic Inactivation of RasGAPs Activates RAS Signaling in a Subset of Luminal B Breast Cancers.
Epigenomic Inactivation of RasGAPs Activates RAS Signaling in a Subset of Luminal B Breast Cancers.
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DOI：
10.1158/2159-8290.cd-16-1423
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发表时间：
2017-02
期刊：
影响因子：
28.2
通讯作者：
Gray JW
中科院分区：
文献类型：
--
作者：
Sears R;Gray JW
侵袭性Lumina B乳腺癌的侵袭和转移是由Ras-GAPs、DAB2IP和RASAL2的失活共同驱动的。这两种蛋白的失活增加Ras活性并驱动入侵，而DAB2IP的失活特异性地促进NF-kB介导的EMT
Invasion and metastasis of a subset of aggressive Lumina B breast cancers is driven by the concomitant inactivation of the Ras-GAPs, DAB2IP and RASAL2. Inactivation of both proteins increases Ras activity and drives invasion while inactivation of DAB2IP specifically promotes NF-kB mediated EMT