Regioselective lithiation of benzyl imidazole: Synthesis and evaluation of new organocatalysts for trans -diol functionalization.
Regioselective lithiation of benzyl imidazole: Synthesis and evaluation of new organocatalysts for trans -diol functionalization.
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苄基咪唑的区域选择性锂化：用于反式二醇官能化的新型有机催化剂的合成和评价。
DOI：
10.1080/00397911.2019.1655766
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发表时间：
2019
影响因子：
2.1
通讯作者：
Carter, Rich
中科院分区：
文献类型：
--
作者：
El-Mansy, Mohamed;Ghosh, Ankan;Cheong, Paul Ha-Yeon;Carter, Rich
在−78 °C下，用n-BuLi成功地催化了苄基咪唑的锂化合成，并用掺氢方法进行了验证。用一系列不同的亲电试剂研究了锂化苯并咪唑的化学反应。利用该方法合成了用于反式二醇官能化的新型反式和合成二苯基有机催化剂。
Benzyl imidazole was successfully lithiated using n-BuLi at −78 °C and verified by deuterium incorporation. The chemical reaction of the lithiated benzimidazole was explored with a series of different electrophiles. This approach was utilized to synthesize newantiandsyndiphenyl organocatalysts fortrans-diol functionalization.