Diabetes, related conditions, and dementia.

Diabetes, related conditions, and dementia.
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DOI:
10.1016/j.jns.2010.08.063
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发表时间:
2010-12-15
影响因子:
4.4
通讯作者:
Luchsinger, Jose A.
Luchsinger, Jose A.
中科院分区:
医学3区
文献类型:
--
作者:
Luchsinger, Jose A.

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本文简要回顾了将2型糖尿病(T2D)及其前驱疾病(肥胖和高胰岛素血症升高)与痴呆联系起来的流行病学证据。中年肥胖症与痴呆症的高风险有关,但关于老年人这种关联的数据是相互矛盾的。高胰岛素血症是高肥胖和胰岛素抵抗的结果,也与痴呆的高风险有关,包括迟发性阿尔茨海默病(LOAD)。研究一直表明T2D与更高的痴呆风险有关,但与LOAD相比,血管性痴呆的相关性更强。这些关联的一个含义是,用于预防T2D的策略可以用于预防痴呆症。目前,T2D预防和治疗方面的几项研究正在测量认知结果,并将提供有关T2D治疗和预防是否可以预防认知衰退和痴呆的信息。
This manuscript provides a brief review of the epidemiologic evidence linking type 2 diabetes (T2D) and its precursor conditions, elevated adiposity and hyperinsulinemia, to dementia. Elevated adiposity in middle age is related to a higher risk of dementia but the data on this association in old age is conflicting. Hyperinsulinemia, a consequence of higher adiposity and insulin resistance is also related to a higher risk of dementia, including late onset Alzheimer’s disease (LOAD). Studies have consistently shown a relation of T2D with higher dementia risk, but the associations are stronger for vascular dementia compared to LOAD. One implication of these associations is that strategies used to prevent T2D can be used to prevent dementia. Several studies in the prevention and treatment of T2D are currently measuring cognitive outcomes and will provide information on whether T2D treatment and prevention can prevent cognitive decline and dementia.
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