Lower Blood Alcohol Concentration Among HIV-Positive Versus HIV-Negative Individuals Following Controlled Alcohol Administration.
Lower Blood Alcohol Concentration Among HIV-Positive Versus HIV-Negative Individuals Following Controlled Alcohol Administration.
复制标题
控制饮酒后，艾滋病毒阳性者与艾滋病毒阴性者的血液酒精浓度较低。
DOI：
10.1111/acer.13816
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Rehm,Jürgen
中科院分区：
文献类型：
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作者：
Shuper,PaulA;Joharchi,Narges;Rehm,Jürgen
背景虽然有人声称，HIV阳性个体在急性饮酒后可能比HIV阴性个体经历更大程度的中毒，但迄今为止还没有研究对这一假设进行实证检验。目前的调查需要一个随机对照实验，以确定是否管理的体重规定剂量的酒精会导致差异血液酒精浓度（BAC）之间的艾滋病毒阳性与艾滋病毒阴性的男子。（n= 76例HIV阳性和n = 67例HIV阴性;平均年龄= 42.9）在15分钟时间范围内饮用基于0.7 g酒精/kg体重配方的饮料。在2个设定的时间点（摄入后10和13分钟）通过呼吸测醉器评估BAC，然后定期评估直到解毒（BAC < 0.040%）。主要结果包括（i）曲线下面积（AUC），根据所有的BAC读数计算，（ii）“BAC-EXP”，定义为饮用后13分钟的BAC阅读，和（iii）BAC-PEAK，定义为一个人记录的最高BAC阅读。P=0.008）和BAC‐PEAK（t（141）= 2.29，P =0.023）在HIV阳性受试者中显著低于HIV阴性受试者。这些影响在控制年龄、种族和基于AUDIT的危险饮酒分类的多变量模型中持续存在。在HIV阳性样本中，基于HIV病毒载量可检测性、抗逆转录病毒治疗（ART）状态或ART adherence.ConclusionsThe管理控制的、体重指定剂量的酒精导致HIV阳性与HIV阴性参与者的BAC较低。这些差异可能来自与HIV血清阳性相关的体脂百分比降低和胃排空延迟;然而，需要进一步研究来验证这些机制。在未来涉及HIV阳性样本的酒精给药实验中，可能需要基于HIV血清状态的独特酒精给药配方。
BackgroundAlthough it has been purported that HIV‐positive individuals may experience a greater degree of intoxication than HIV‐negative individuals following acute alcohol consumption, no research to date has empirically tested this supposition. The present investigation entailed a randomized controlled experiment to identify whether the administration of a weight‐specified dose of alcohol would lead to differential blood alcohol concentrations (BACs) among HIV‐positive versus HIV‐negative men.MethodsIn a specialized barroom laboratory, 143 men (n= 76 HIV‐positive andn= 67 HIV‐negative; mean age = 42.9) consumed beverages based on a formulation of 0.7 g alcohol/kg body weight over a 15‐minute time frame. BAC was assessed via breathalyzer at 2 set time points (10 and 13 minutes postconsumption) and then periodically until detoxification (BAC < 0.040%). Primary outcomes included (i) area under the curve (AUC), calculated based on all of one's BAC readings, (ii) “BAC‐EXP,” defined as one's BAC reading 13 minutes postconsumption, and (iii) BAC‐PEAK, defined as one's highest recorded BAC reading.ResultsContrary to predictions, AUC (t(141) = 2.23,p=0.027), BAC‐EXP (t(141) = 2.68,p=0.008), and BAC‐PEAK (t(141) = 2.29,p=0.023) were significantly lower among HIV‐positive versus HIV‐negative participants. These effects were sustained in multivariable models controlling for age, race, and AUDIT‐based hazardous drinking classification. Among the HIV‐positive sample, outcomes did not significantly differ based on HIV viral load detectability, antiretroviral therapy (ART) status, or ART adherence.ConclusionsThe administration of a controlled, weight‐specified dose of alcohol led to lower BACs among HIV‐positive versus HIV‐negative participants. These differences might derive from decreased body fat percentage and delayed gastric emptying associated with HIV seropositivity; however, additional research is necessary to verify these mechanisms. Unique alcohol dosing formulas based on HIV serostatus may be required in future alcohol administration experiments involving HIV‐positive samples.