Novelty-Induced Phase-Locked Firing to Slow Gamma Oscillations in the Hippocampus: Requirement of Synaptic Plasticity
Novelty-Induced Phase-Locked Firing to Slow Gamma Oscillations in the Hippocampus: Requirement of Synaptic Plasticity
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DOI：
10.1016/j.neuron.2015.05.012
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发表时间：
2015-06-03
期刊：
影响因子：
16.2
通讯作者：
Tashiro, Ayumu
中科院分区：
文献类型：
--
作者：
Kitanishi, Takuma;Ujita, Sakiko;Tashiro, Ayumu
时间上精确的神经元放电相位锁定到伽马振荡被认为介导神经元群体的动态相互作用，这对于高阶功能（例如学习和记忆）的信息处理是必不可少的。然而，决定相位锁定的细胞机制仍不清楚。通过设计一种病毒介导的方法，从基因操纵的神经元进行多四极记录，我们证明了突触可塑性依赖于AMPA的GluR 1亚基。（α-氨基-3-羟基-5-甲基-4-异恶唑丙酸酯）受体介导新体验期间海马CA 1区神经元放电的两种动态变化：建立锁相放电以减缓伽马振荡和快速形成位置细胞的空间放电模式。结果表明，一系列潜在的事件的收购新的空间信息：缓慢的伽马振荡，起源于CA 3区，诱导两个GluR 1依赖的变化CA 1神经元放电，这反过来又决定了信息流的神经元-神经内嗅系统。
Temporally precise neuronal firing phase-locked to gamma oscillations is thought to mediate the dynamic interaction of neuronal populations, which is essential for information processing underlying higher-order functions such as learning and memory. However, the cellular mechanisms determining phase locking remain unclear. By devising a virus-mediated approach to perform multi-tetrode recording from genetically manipulated neurons, we demonstrated that synaptic plasticity dependent on the GluR1 subunit of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptor mediates two dynamic changes in neuronal firing in the hippocampal CA1 area during novel experiences: the establishment of phase-locked firing to slow gamma oscillations and the rapid formation of the spatial firing pattern of place cells. The results suggest a series of events potentially underlying the acquisition of new spatial information: slow gamma oscillations, originating from the CA3 area, induce the two GluR1-dependent changes of CA1 neuronal firing, which in turn determine information flow in the hippo-campal-entorhinal system.