Lesion analysis of the brain areas involved in language comprehension
Lesion analysis of the brain areas involved in language comprehension
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DOI：
10.1016/j.cognition.2003.11.002
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发表时间：
2004-05-01
期刊：
影响因子：
3.4
通讯作者：
Jaeger, JJ
中科院分区：
文献类型：
--
作者：
Dronkers, NF;Wilkins, DP;Jaeger, JJ
传统上，大脑的皮质区域与语言的理解有关，是Wernicke的区域和Broca的区域。但是，最近的证据表明，其他大脑区域也可能参与这一复杂过程。本文介绍了评估大量脑部受伤患者的机会，以确定哪些病变的大脑领域可能影响语言理解。在Curtiss-Yamada综合语言评估的11个子测验中评估了64个慢性左半球中风患者 - 接受（Cycle-R; Curtiss，S。，＆Yamada，J。（1988）。Curtiss-Yamada综合语言评估。未发表。测试，UCLA）。还参加了八名右半球中风患者和15名神经系统正常的老年对照。要求患者从三个或四个选择的阵列中选择一条线图，以最能描述一个审计的句子的内容。将从结构神经影像学获得的患者病变重建到模板上，并输入基于素的病变 - 症状映射（VLSM； Bates； Bates，E。，Wilson，S. ，R。T。和Dronkers，N。F。（2003年）。 VLSM是一种大脑行为映射技术，它以逐体素的基础评估所有患者的伤害和行为表现区域之间的关系，类似于对功能神经成像数据的分析。结果表明，对五个左半球大脑区域的病变影响了自行车-R的性能，包括后颞回和潜在的白质，前颞上回，颞上沟和角度回，上的颞上回和布罗德曼地区的中部额叶皮质46，布罗德曼的下部回回第47区。没有发现对Broca和Wernicke地区的病变会显着改变对这一特定措施的语言理解。进一步的分析表明，中间的颞回可能对在单词层面上的理解更为重要，而其他区域可能在句子的层面上发挥更大的作用。这些结果与最近功能性神经影像学研究中看到的结果一致，并提供补充数据，以了解语言理解的大脑领域。 （c）2004 Elsevier B.V.保留所有权利。
The cortical regions of the brain traditionally associated with the comprehension of language are Wernicke's area and Broca's area. However, recent evidence suggests that other brain regions might also be involved in this complex process. This paper describes the opportunity to evaluate a large number of brain-injured patients to determine which lesioned brain areas might affect language comprehension. Sixty-four chronic left hemisphere stroke patients were evaluated on 11 subtests of the Curtiss-Yamada Comprehensive Language Evaluation - Receptive (CYCLE-R; Curtiss, S., & Yamada, J. (1988). Curtiss-Yamada Comprehensive Language Evaluation. Unpublished test, UCLA). Eight right hemisphere stroke patients and 15 neurologically normal older controls also participated. Patients were required to select a single line drawing from an array of three or four choices that best depicted the content of an auditorily-presented sentence. Patients' lesions obtained from structural neuroimaging were reconstructed onto templates and entered into a voxel-based lesion-symptom mapping (VLSM; Bates, E., Wilson, S., Saygin, A. P., Dick, F., Sereno, M., Knight, R. T., & Dronkers, N. F. (2003). Voxel-based lesion-symptom mapping. Nature Neuroscience, 6(5), 448-450.) analysis along with the behavioral data. VLSM is a brain-behavior mapping technique that evaluates the relationships between areas of injury and behavioral performance in all patients on a voxel-by-voxel basis, similar to the analysis of functional neuroimaging data. Results indicated that lesions to five left hemisphere brain regions affected performance on the CYCLE-R, including the posterior middle temporal gyrus and underlying white matter, the anterior superior temporal gyrus, the superior temporal sulcus and angular gyrus, mid-frontal cortex in Brodmann's area 46, and Brodmann's area 47 of the inferior frontal gyrus. Lesions to Broca's and Wernicke's areas were not found to significantly alter language comprehension on this particular measure. Further analysis suggested that the middle temporal gyrus may be more important for comprehension at the word level, while the other regions may play a greater role at the level of the sentence. These results are consistent with those seen in recent functional neuroimaging studies and offer complementary data in the effort to understand the brain areas underlying language comprehension. (C) 2004 Elsevier B.V. All rights reserved.