Gastrointestinal stem cells. II. Intestinal stem cells
Gastrointestinal stem cells. II. Intestinal stem cells
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DOI：
10.1152/ajpgi.00160.2005
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发表时间：
2005-09-01
影响因子：
4.5
通讯作者：
Cheng, H
中科院分区：
文献类型：
--
作者：
Bjerknes, M;Cheng, H
目前对小肠上皮干细胞及其后代的识别、分布和调控的观点进行了讨论。最近的工作涉及Wnt信号在干细胞和祖细胞增殖中的作用，Notch信号在上皮细胞谱系中的参与，以及Hedgehog和骨形态发生蛋白家族在隐窝形成中的作用。我们很幸运，这些论文中有许多是由独立团体成对发表的。我们试图找出共同点，在彼此的背景下重新解释彼此，并指出继续取得进展的方向。
Current views of the identity, distribution, and regulation of small intestinal epithelial stem cells and their immediate progeny are discussed. Recent works implicating Wnt signaling in stem and progenitor proliferation, the involvement of Notch signaling in epithelial lineage specification, and the role of hedgehog and bone morphogenetic protein families in crypt formation are integrated. We had the good fortune that many of these papers came in pairs from independent groups. We attempt to identify points of agreement, reinterpret each in the context of the other, and indicate directions for continued progress.