Autologous melanoma-induced activation of regulatory T cells that suppress cytotoxic response.
Autologous melanoma-induced activation of regulatory T cells that suppress cytotoxic response.
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DOI：
10.4049/jimmunol.145.7.2359
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发表时间：
1990-10
影响因子：
4.4
通讯作者：
N. Chakraborty;D. Twardzik;M. Sivanandham;M. T. Ergin;K. Hellstrom;B. Mukherji
中科院分区：
文献类型：
--
作者：
N. Chakraborty;D. Twardzik;M. Sivanandham;M. T. Ergin;K. Hellstrom;B. Mukherji
宿主对自体人类癌症的免疫反应受到免疫调节网络的调节。我们发现，在两种自体系统中，来自黑色素瘤淋巴结淋巴细胞和来自自体黑色素瘤细胞刺激的PBL的某些CD4+T细胞克隆，选择性地下调PBL对各自的自体黑色素瘤细胞的细胞毒免疫反应的诱导。在这两个系统中，只有针对自体黑色素瘤细胞的细胞毒性反应被抑制。1例对EBV感染的自体淋巴母细胞系的细胞毒反应和另1例对同种异体靶点的细胞毒反应未受影响。当T细胞克隆与自身黑色素瘤细胞和APC共同培养时，除了选择性地表达对自身黑色素瘤细胞的抑制活性外，T细胞克隆还上调了它们的Tac受体。这些结果支持在体外存在肿瘤抗原驱动的调节性T细胞激活，从而影响针对自体人类黑色素瘤的细胞毒性免疫反应。
The host immune response toward autologous human cancer is subject to regulation by the immunoregulatory network. We show that certain CD4+ T cell clones, derived from melanoma involved lymph node lymphocytes and from PBL stimulated by autologous melanoma cells, selectively down-regulated the induction of cytotoxic immune response of PBL against the respective autologous melanoma cells in two autologous systems. In both systems, only the generation of cytotoxic response against the autologous melanoma cells were suppressed. Cytotoxic response against EBV-infected autologous lymphoblastoid cell line in one case and cytotoxic responses against allogeneic targets in the other were not affected. In addition to suppressor activity selectively expressed against the autologous melanoma cells, the T cell clones up-regulated their Tac receptors when cocultured with the autologous melanoma cells and APC. These results support the existence of a putative tumor Ag-driven activation of regulatory T cells that affect cytotoxic immune response, in vitro, against autologous human melanoma.