The long term prognostic significance of oestrogen receptor analysis in early carcinoma of the breast.
The long term prognostic significance of oestrogen receptor analysis in early carcinoma of the breast.
复制标题
雌激素受体分析在乳腺癌早期癌中的长期预后意义。
DOI：
10.1038/bjc.1991.249
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发表时间：
1991-07
影响因子：
8.8
通讯作者：
Nicholson, R
中科院分区：
文献类型：
--
作者：
Winstanley, J;Cooke, T;George, W D;Murray, G;Holt, S;Croton, R;Griffiths, K;Nicholson, R
在一项前瞻性研究中评估了雌激素受体的长期预后意义，该研究纳入了767例1975年至1981年间的1期和2期乳腺癌患者，这些患者接受了全腋窝清扫或淋巴结取样的乳房切除术。采用葡聚糖包覆炭法测定雌激素受体结合，中位随访时间为11年。396例（54%）肿瘤中存在雌激素受体。雌激素受体的缺失与高组织学分级的肿瘤有关，但在淋巴结状态和肿瘤大小之间没有关系。雌激素受体状态不能预测整个组的生存率，也不能根据淋巴结状态分层。在多变量分析中，淋巴结状态和肿瘤大小都是独立的预后因素，但雌激素受体没有达到统计学意义。
The long term prognostic significance of oestrogen receptors was assessed in a prospective study of 767 patients presenting between the years 1975 and 1981 with stage 1 and 2 breast cancer treated by mastectomy with either full axillary dissection or nodal sampling. Oestrogen receptor binding was determined by a dextran coated charcoal method and median follow up was 11 years. Oestrogen receptors were present in 396 (54%) of tumours. Absence of oestrogen receptors was associated with tumours of high histological grade, but there was no relationship between nodal status or tumour size. Oestrogen receptor status did not predict survival for the group as a whole or when stratified by nodal status. In multivariate analysis both nodal status and tumour size were powerful independent prognostic factors, but oestrogen receptors failed to achieve statistical significance.