PHYSIOLOGICAL-RESPONSES TO INTRANASAL DOSE-RESPONSE CHALLENGES WITH HISTAMINE, METHACHOLINE, BRADYKININ, AND PROSTAGLANDIN IN ADULT VOLUNTEERS WITH AND WITHOUT NASAL ALLERGY
PHYSIOLOGICAL-RESPONSES TO INTRANASAL DOSE-RESPONSE CHALLENGES WITH HISTAMINE, METHACHOLINE, BRADYKININ, AND PROSTAGLANDIN IN ADULT VOLUNTEERS WITH AND WITHOUT NASAL ALLERGY
复制标题
DOI：
10.1016/s0091-6749(05)80156-3
复制
发表时间：
1990-12-01
影响因子：
14.2
通讯作者：
SKONER, DP
中科院分区：
文献类型：
--
作者：
DOYLE, WJ;BOEHM, S;SKONER, DP
对10名特应性受试者和10名非特应性受试者进行鼻腔通畅度、分泌物重量、肺功能、咽鼓管功能、中耳功能和鼻腔吸入组胺、缓激肽、乙酰甲胆碱、前列腺素D2和前列腺素F2-α(PGF2-α)攻击后症状的剂量-反应曲线(剂量分别为0.01、0.05、0.1、0.5、1和5 mg)测定。结果显示，用PGF2-α刺激可提高鼻腔通畅率，而用所有其他物质刺激则降低鼻腔通畅率。引起鼻腔充血反应的物质之间的关系是前列腺素D2和GT；组胺和GT；缓激肽和偏乙酰胆碱。在咽鼓管功能障碍挑战后的发展中也注意到类似的效果排序。与所有其他物质相比，组胺激发后分泌重量显著增加。只有在使用PGF2-α攻击后，才能观察到肺功能的下降，尽管这种影响在统计学上没有显著意义。在用任何物质挑战时，没有观察到中耳压力的变化。只有组胺刺激会引起打喷嚏，而前列腺素中的任何一种都会引起咳嗽。除偏甲胆碱外，所有物质都会引起鼻漏、充血和喉咙痛的症状。缓激肽在引起与“疼痛/压力”相关的症状方面特别有效。除分泌物重量外，特应性和非特应性受试者之间的反应差异无统计学意义。这些结果证明了对鼻腔攻击的生理和症状反应的介体特异性。
The dose-response (dose, 0.01, 0.05, 0.1, 0.5, 1, and 5 mg) profiles of 10 atopic and 10 nonatopic subjects were determined for nasal patency, secretion weight, pulmonary function, eustachian tube function, middle-ear function, and symptoms after intranasal inhalation challenges with histamine, bradykinin, methacholine, prostaglandin D2, and prostaglandin F2-alpha (PGF2-alpha). Results demonstrated that challenge with PGF2-alpha increased nasal patency, whereas challenge with all other substances decreased patency. The relationship between substances in eliciting a nasal congestive response was prostaglandin D2 > histamine > bradykinin > metacholine. A similar effect ordering was noted for the postchallenge development of eustachian tube dysfunction. Secretion weights were significantly greater after challenge with histamine compared to all other substances. A decrease in pulmonary function was observed only after challenge with PGF2-alpha, although the effect was not statistically significant. No changes in middle-ear pressure were observed for challenges with any of the substances. Only histamine challenge provoked sneezing, whereas challenge with either of the prostaglandins provoked cough. With the exception of metacholine, all substances caused symptoms of rhinorrhea, congestion, and sore throat. Bradykinin was particularly effective in provoking "pain/pressure"-related symptoms. With the exception of secretion weight, the differences between responses of atopic and nonatopic subjects were not statistically significant. These results document mediator specificity in the physiologic and symptomatic responses to intranasal challenge.