The microglial phagocytic role with specific plaque types in the Alzheimer disease brain
The microglial phagocytic role with specific plaque types in the Alzheimer disease brain
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DOI：
10.1016/j.neurobiolaging.2003.12.026
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发表时间：
2004-05-01
影响因子：
4.2
通讯作者：
Ard, MD
中科院分区：
文献类型：
--
作者：
D'Andrea, MR;Cole, GM;Ard, MD
阿尔茨海默病（AD）涉及与淀粉样斑块相关的神经胶质炎症。小胶质细胞在阿尔茨海默病脑中的作用是有争议的，因为尚不清楚小胶质细胞是形成斑块的淀粉样蛋白原纤维还是在巨噬细胞吞噬作用中对它们作出反应。此外，目前尚不清楚为什么小胶质细胞优先与某些淀粉样斑块类型相关。本综述将提供大量证据来支持小胶质细胞在大脑中的吞噬作用，并解释为什么小胶质细胞通常与特定斑块类型相关，这可能通过其独特的形成机制来解释。总之，目前的数据表明斑块相关的小胶质细胞激活通常是在AD大脑中特异性淀粉样斑块形成之后发生的。(C) 2004爱思唯尔公司版权所有。
Alzheimer disease (AD) involves glial inflammation associated with amyloid plaques. The role of the microglial cells in the AD brain is controversial, as it remains unclear if the microglia form the amyloid fibrils of plaques or react to them in a macrophage-phagocytic role. Also, it is not known why microglia are preferentially associated with some amyloid plaque types. This review will provide substantial evidence to support the phagocytic role of microglia in the brain as well as explain why microglia are generally associated with specific plaque types that may be explained through their unique mechanisms of formation. In summary, the data presented suggests that plaque associated microglial activation is typically subsequent to specific amyloid plaque formations in the AD brain. (C) 2004 Elsevier Inc. All rights reserved.