Neutrophil-tumor cell cannibalism in oral squamous cell carcinoma
Neutrophil-tumor cell cannibalism in oral squamous cell carcinoma
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DOI：
10.1111/jop.12157
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发表时间：
2014-07-01
影响因子：
3.3
通讯作者：
Sarode, Gargi S.
中科院分区：
文献类型：
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作者：
Sarode, Sachin C.;Sarode, Gargi S.
背景：同类相食是指肿瘤细胞相互吞噬的现象。最近的报道显示肿瘤细胞吞噬其他细胞（异种相食），如中性粒细胞，淋巴细胞和红细胞。目的：对500例口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）进行回顾性组织病理学分析，探讨嗜癌细胞-肿瘤细胞自食现象（Antithromal-tumor cell cannibalism，NTCC）与临床病理参数的关系。选择仅显示坦率NTCC的病例。结果：7例（1.4%）口腔鳞癌组织病理学表现为典型的极端非典型鳞状细胞癌。排除17例（3.4%）偶发性孤立性NTCC。所有病例均为低分化，有颈淋巴结转移。免疫组化结果显示，CD 68和溶菌酶标记物在口腔鳞癌中呈轻度（+）~中度（++）阳性表达。结论：口腔鳞癌中的NTCC可作为一种预测口腔鳞癌生物学行为的指标，并可作为一种有价值的预后指标。肿瘤细胞表现出巨噬细胞表型和细胞消化可通过溶酶体酶活性介导。
BACKGROUND: Cannibalism was recognized as a phenomenon seen mainly with the tumor cells ingesting other tumor cells. Recent reports have shown tumor cell engulfing other cells (xeno-cannibalism) as well, such as neutrophils, lymphocytes and erythrocytes. But no such finding has been reported in oral squamous cell carcinoma (OSCC) in the literature till date.OBJECTIVE: Retrospective histopathological analysis of OSCC for identification of neutrophil-tumor cell cannibalism (NTCC) and its correlation with clinico-pathological parameters.METHODS: The hematoxylin and eosin stained tissue sections of 500 OSCC cases were thoroughly screened at high power magnification (400X) for NTCC. Cases showing only frank NTCC were selected. Cases were subjected to immunohistochemical analysis using CD68 and lysozyme.RESULTS: Seven (1.4%) cases of OSCC which showed classical features of extreme NTCC on histopathological examination. Seventeen Cases (3.4%) showing occasional isolated NTCC were excluded. All the cases were poorly differentiated and showed cervical lymph node metastasis. Immunohistochemical analysis showed mild (+) to moderate (++) positivity in tumor cells for CD68 and lysozyme markers.CONCLUSION: NTCC in OSCC can predict the biological behavior and could serve as a useful prognostic marker in future. Tumor cell displaying macrophage phenotype and cell digestion could be mediated through lysosomal enzyme activity.