Determinants of Ethnic Differences in Cytomegalovirus, Epstein-Barr Virus, and Herpes Simplex Virus Type 1 Seroprevalence in Childhood
Determinants of Ethnic Differences in Cytomegalovirus, Epstein-Barr Virus, and Herpes Simplex Virus Type 1 Seroprevalence in Childhood
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DOI：
10.1016/j.jpeds.2015.11.014
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发表时间：
2016-03-01
影响因子：
5.1
通讯作者：
Moll, Henriette A.
中科院分区：
文献类型：
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作者：
Jansen, Michelle A. E.;van den Heuvel, Diana;Moll, Henriette A.
目的确定是否有种族差异，巨细胞病毒（CMV），EB病毒（EBV），单纯疱疹病毒1型（HSV-1）的血清阳性率在6岁的儿童，当存在时，以评估这些差异如何可以解释的社会人口和环境factors.Study设计本研究是嵌入在一个多种族人群为基础的前瞻性队列研究。采用酶联免疫吸附试验测定了4464名儿童（中位年龄6.0岁）血清中抗CMV、EBV和HSV-1的IgG水平。通过问卷调查评估人口统计学和特征信息。结果非西方种族是CMV（aOR，2.16; 95%CI 1.81-2.57）、EBV（1.76; 1.48-2.09）和HSV-1血清阳性（1.52; 1.39-1.66）的独立危险因素。在种族群体中，CMV血清阳性率范围为29%至65%，EBV为43%至69%，HSV-1为13%至39%。家庭净收入低，母亲教育水平低，拥挤和生活方式因素解释了高达48%的HSV-1血清阳性率的种族差异，高达39%的EBV血清阳性率的种族差异。这些因素并没有解释种族差异CMV血清阳性率。结论社会经济地位和生活方式相关的因素只解释了一部分的大的种族差异EBV和HSV-1血清阳性率，而他们不解释种族差异CMV血清阳性率在儿童期。
Objective To identify whether there are ethnic differences in cytomegalovirus (CMV), Epstein-Barr virus (EBV), and herpes simplex virus type 1 (HSV-1) seroprevalence rates in children at 6 years of age, and when present, to evaluate how these differences can be explained by sociodemographic and environmental factors.Study design This study was embedded within a multi-ethnic population-based prospective cohort study. Serum IgG levels against CMV, EBV, and HSV-1 were measured by enzyme-linked immunosorbent assay in 4464 children (median age 6.0 years). Information on demographics and characteristics were assessed by questionnaires. Herpesvirus seroprevalences between Surinamese-Creole, Surinamese-Hindustani, Turkish, Moroccan, Cape Verdean Antillean, and Native Dutch children were compared.Results Non-Western ethnicity was an independent risk factor for CMV (aOR, 2.16; 95% CI 1.81-2.57), EBV (1.76; 1.48-2.09), and HSV-1 seropositivity (1.52; 1.39-1.66). Among the ethnic groups, CMV seroprevalences ranged between 29% and 65%, EBV between 43% and 69%, and HSV-1 between 13% and 39%. Low family net household income, low maternal educational level, crowding, and lifestyle factors explained up to 48% of the ethnic differences in HSV-1 seroprevalences, and up to 39% of the ethnic differences in EBV seroprevalences. These factors did not explain ethnic differences in CMV seroprevalences.Conclusions Socioeconomic position and factors related to lifestyle explain only a part of the large ethnic differences in EBV and HSV-1 seroprevalences, whereas they do not explain ethnic differences in CMV seroprevalences in childhood.