Genetic susceptibility testing for Alzheimer disease: Motivation to obtain information and control as precursors to coping with increased risk
Genetic susceptibility testing for Alzheimer disease: Motivation to obtain information and control as precursors to coping with increased risk
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DOI：
10.1016/j.pec.2006.03.002
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发表时间：
2006-12-01
影响因子：
3.5
通讯作者：
Biesecker, Barbara B.
中科院分区：
文献类型：
--
作者：
Gooding, Holly C.;Linnenbringer, Erin L.;Biesecker, Barbara B.
目的：本研究调查评估，包括动机，和应对偏好进行载脂蛋白E（APOE）的敏感性测试阿尔茨海默病（AD）。方法：参与者是60名成年儿童的个人受影响的AD参加了一项试验，调查使用和影响的APOE敏感性测试。进行了一项探索性的定性研究，参与者接受了采访，他们的测试经验。结果如下：大多数参与者认为基因检测提供了有价值的信息，可以帮助指导未来的医疗保健决策，并满足他们对生活风险增加的情感担忧。参与者有关他们的动机基因检测，他们对发展AD的担忧，偏好寻求有关健康威胁的信息，并需要感觉在他们的health.Results的控制：大多数参与者认为基因检测提供有价值的信息，可以帮助指导未来的医疗保健决策，并满足他们的情感关注生活在增加的风险。参与者将他们进行基因检测的动机与他们对发展AD的担忧、寻求健康威胁信息的偏好以及需要控制自己的健康状况联系起来。结论：即使没有预防或治疗方案，基因检测也可能是一些高危人群的一种有用的应对策略。一旦测试成为临床可用，从业人员需要解决的价值和测试的局限性，以及评估和努力，以科普。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Objective: This study investigated appraisals, including motivation, and coping preferences for undergoing Apolipoprotein E (APOE) susceptibility testing for Alzheimer disease (AD).Methods: Participants were 60 adult children of individuals affected with AD enrolled in a trial investigating use and impact of APOE susceptibility testing. An exploratory qualitative study was undertaken in which participants were interviewed about their testing experience. Results: Most participants viewed genetic testing as providing valuable information that could help direct future health care decisions and meet their emotional concerns about living at increased risk. Participants related their motivation for genetic testing to their worries about developing AD, preference to seek information about health threats, and need to feel in control of their health.Results: Most participants viewed genetic testing as providing valuable information that could help direct future health care decisions and meet their emotional concerns about living at increased risk. Participants related their motivation for genetic testing to their worries about developing AD, preference to seek information about health threats, and need to feel in control of their health.Conclusion: Even without prevention or treatment options, genetic testing may be a useful coping strategy for some at-risk individuals.Practice implications: Once testing becomes clinically available, practitioners need to address the value and limitations of testing as well as appraisals and efforts to cope. (c) 2006 Elsevier Ireland Ltd. All rights reserved.