Comparison of Macular Integrity Assessment (MAIA ™), MP-3, and the Humphrey Field Analyzer in the Evaluation of the Relationship between the Structure and Function of the Macula.
Comparison of Macular Integrity Assessment (MAIA ™), MP-3, and the Humphrey Field Analyzer in the Evaluation of the Relationship between the Structure and Function of the Macula.
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DOI：
10.1371/journal.pone.0151000
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Tsujikawa A
中科院分区：
文献类型：
--
作者：
Hirooka K;Misaki K;Nitta E;Ukegawa K;Sato S;Tsujikawa A
本研究旨在比较通过MAIATM（黄斑完整性评估）、MP-3或Humphry视野分析仪（HFA）测量的黄斑视野（VF）平均敏感度与神经节细胞和内丛状层（GCA）厚度之间的关系。这项横断面研究检查了73名青光眼患者和19名正常人。所有受试者均通过Cirrus HD-OCT测量GCA厚度，并使用MAIATM、MP-3或HFA进行静态阈值视野检查。在视网膜视图中使用VF和OCT来检查VF敏感性和GCA厚度之间的全局关系以及上级半视网膜和下级半视网膜。用斯皮尔曼相关分析法分析GCA厚度与黄斑敏感度的关系。对于每种仪器，使用分贝量表观察到统计学上显著的黄斑VF灵敏度（dB）和GCA厚度关系（R = 0.547-0.687，均P < 0.001）。通过HFA观察到全局（R = 0.682）和上级半侧视网膜（R = 0.594）GCA厚度-VF平均灵敏度的最高相关性。MP-3观察到下半视网膜（R = 0.687）GCA厚度-VF平均灵敏度的最高相关性。然而，在三种VF测量仪器中，没有发现结构-功能关系的显著差异。所有三种VF测量仪器在中央VF中发现了相似的结构-功能关系。
This study was conducted in order to compare relationships between the macular visual field (VF) mean sensitivity measured by MAIATM (Macular Integrity Assessment), MP-3, or Humphry field analyzer (HFA) and the ganglion cell and inner plexiform layer (GCA) thicknesses. This cross-sectional study examined 73 glaucoma patients and 19 normal subjects. All subjects underwent measurements for GCA thickness by Cirrus HD-OCT and static threshold perimetry using MAIATM, MP-3, or HFA. VF and OCT in the retinal view were used to examine both the global relationship between the VF sensitivity and GCA thickness, and the superior hemiretina and inferior hemiretina. The relationship between the GCA thickness and macular sensitivity was examined by Spearman correlation analysis. For each instrument, statistically significant macular VF sensitivity (dB) and GCA thickness relationships were observed using the decibel scale (R = 0.547–0.687, all P < 0.001). The highest correlation for the global (R = 0.682) and the superior hemiretina (R = 0.594) GCA thickness-VF mean sensitivity was observed by the HFA. The highest correlation for the inferior hemiretina (R = 0.687) GCA thickness-VF mean sensitivity was observed by the MP-3. Among the three VF measurement instruments, however, no significant differences were found for the structure-function relationships. All three VF measurement instruments found similar structure-function relationships in the central VF.