Nighttime eating and breast cancer among Chinese women in Hong Kong.
Nighttime eating and breast cancer among Chinese women in Hong Kong.
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DOI：
10.1186/s13058-017-0821-x
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发表时间：
2017-03-17
期刊：
影响因子：
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通讯作者：
Yang XR
中科院分区：
文献类型：
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作者：
Li M;Tse LA;Chan WC;Kwok CH;Leung SL;Wu C;Yu WC;Lee PM;Tsang KH;Law SH;Vermeulen R;Gu F;Caporaso NE;Yu IT;Wang F;Yang XR
一项新的研究表明，夜间进食可能会产生几种与乳腺癌高度相关的新陈代谢后果。我们调查了晚上10点后夜间饮食习惯之间的关系。和乳腺癌在香港妇女中的比例。2012-2015年间进行了一项以医院为基础的病例对照研究。共招募了922名乳腺癌患者(病例)和913名医院对照组，并使用包括白天和夜间饮食行为信息的标准问卷进行了采访。我们收集了夜间进食的时间、持续时间、类型和频率。通过非条件多变量Logistic回归计算乳腺癌风险与夜间进食相关变量的优势比(OR)。晚上10点后进食与乳腺癌显著相关，调整后的OR为1.5(95%可信区间(CI)1.06-2.12，P = 0.02)，而且在夜间进食时间最长的女性(≥20年)(调整后的OR = 2.28(95%可信区间1.13-4.61，P = 0.02)和进食晚(午夜至凌晨2点)的女性中，相关性更强。(调整后OR = 为2.73，95%CI为1.01-6.99，P = 为0.04)。有趣的是，夜间进食只与主食(OR = 2.16，95%可信区间1.42-3.29，P <； 0.001)的女性有关，而与那些将蔬菜或水果作为夜间正餐的女性无关。在体重指数为25的女性中观察到夜间进食与乳腺癌之间的显著关联(OR = 为2.29，95%可信区间为1.48-3.52，P <； 为0.001)，但在体重指数为25的女性中未观察到这种关联。这项研究的结果表明，夜间进食行为与乳腺癌之间可能存在关联。这些发现需要通过独立的大型研究来证实。本文的在线版本(doi：10.1186/s13058-0170821-x)包含补充材料，授权用户可以使用。
A novel line of research suggests that eating at nighttime may have several metabolic consequences that are highly relevant to breast cancer. We investigated the association between nighttime eating habits after 10 p.m. and breast cancer in Hong Kong women. A hospital-based case-control study was conducted during 2012–2015. A total of 922 patients with incident breast cancer (cases) and 913 hospital controls were recruited and interviewed using a standard questionnaire including information on eating behavior during both daytime and nighttime. We collected the timing, duration, types and frequencies of food intake of eating at nighttime. Odds ratios (ORs) for the risk of breast cancer in relation to nighttime eating-related variables were calculated by unconditional multivariable logistic regression. Eating at night after 10 pm was significantly associated with breast cancer with an adjusted OR of 1.50 (95% confidence interval (CI) 1.06–2.12, P = 0.02), and the associations were stronger in women who had the longest duration of nighttime eating (≥20 years) (adjusted OR = 2.28 (95% CI 1.13–4.61, P = 0.02) and who ate late (midnight to 2 a.m.) (adjusted OR = 2.73, 95% CI 1.01–6.99, P = 0.04). Interestingly, nighttime eating was only associated with breast cancer among women who consumed staple foods (OR = 2.16, 95% CI 1.42–3.29, P < 0.001) but not those who ate vegetables or fruits as nighttime meals. The significant association between nighttime eating and breast cancer was observed among women with body mass index (BMI) <25 (OR = 2.29, 95% CI 1.48–3.52, P < 0.001) but not among women with BMI ≥25. Results from this study suggest a possible association between nighttime eating behavior and breast cancer. These findings need to be confirmed by independent large studies. The online version of this article (doi:10.1186/s13058-017-0821-x) contains supplementary material, which is available to authorized users.