β-Catenin in oral cancer: An update on current knowledge
β-Catenin in oral cancer: An update on current knowledge
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DOI：
10.1016/j.oraloncology.2014.06.005
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发表时间：
2014-09-01
期刊：
影响因子：
4.8
通讯作者：
Scully, C.
中科院分区：
文献类型：
--
作者：
Gonzalez-Moles, M. A.;Ruiz-Avila, I.;Scully, C.
β-连环蛋白是一种多功能蛋白。这些功能源自其与细胞膜上、细胞质中和细胞核中的其他细胞蛋白质的相互作用。β-连环蛋白与粘附分子E-钙粘蛋白形成复合物，促进细胞-细胞粘附，从而防止癌症侵袭和进展机制所需的细胞解离。还有一个动态的细胞质β-连环蛋白库，作为细胞外微环境和细胞核之间的连接。细胞质β-连环蛋白在经典Wnt途径中作为细胞核的转录因子，激活各种基因的转录。β-连环蛋白的结构或功能改变可促进癌症进展。本文就β-连环蛋白在口腔癌发生发展中的作用作一综述。(C)2014爱思唯尔有限公司版权所有。
beta-Catenin is a multiple function protein. These functions derive from its interactions with other cell proteins, both on the cell membrane, in the cytoplasm and in the nucleus. beta-Catenin forms a complex with the adhesion molecule E-cadherin, promoting cell-cell adhesion and thereby preventing the cell dissociation that is required for cancer invasion and progression mechanisms. There is also a dynamic pool of cytoplasmic beta-catenin that serves as connection between the extracellular microenvironment and the nucleus. Cytoplasmic beta-catenin acts as a transcription factor for the nucleus in the canonical Wnt pathway, activating the transcription of various genes. Structural or functional alterations of beta-catenin can promote cancer progression. This review addresses the current knowledge on the implications of beta-catenin in the development of oral cancer. (C) 2014 Elsevier Ltd. All rights reserved.