Predicting Adverse Health Outcomes in Long-Term Survivors of a Childhood Cancer.
Predicting Adverse Health Outcomes in Long-Term Survivors of a Childhood Cancer.
复制标题
DOI：
10.3390/children1020063
复制
发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Oeffinger KC
中科院分区：
文献类型：
--
作者：
Moskowitz CS;Oeffinger KC
被诊断为浸润性癌症的儿童和年轻人中，超过80%的人可以在确诊后存活五年或更长时间。这一人群罹患与严重疾病和治疗相关的发病率和过早死亡的风险增加。其中许多不利的健康后果，如心血管疾病和一些第二原发肿瘤，要么具有可改变的危险因素，要么如果及早发现就可以成功治疗。绝对风险模型可以预测发展健康结果的个性化风险，在患者咨询、设计干预研究、形成预防策略和决定监测计划方面都很有用。在这里，我们回顾了现有的直接适用于儿童癌症幸存者的绝对风险预测模型，讨论了绝对风险模型的概念和解释，并研究了这些模型在临床实践和公共卫生中的应用方法。
More than 80% of children and young adults diagnosed with invasive cancer will survive five or more years beyond their cancer diagnosis. This population has an increased risk for serious illness- and treatment-related morbidity and premature mortality. A number of these adverse health outcomes, such as cardiovascular disease and some second primary neoplasms, either have modifiable risk factors or can be successfully treated if detected early. Absolute risk models that project a personalized risk of developing a health outcome can be useful in patient counseling, in designing intervention studies, in forming prevention strategies, and in deciding upon surveillance programs. Here, we review existing absolute risk prediction models that are directly applicable to survivors of a childhood cancer, discuss the concepts and interpretation of absolute risk models, and examine ways in which these models can be used applied in clinical practice and public health.