Increased numbers of CD5+CD19+CD1dhighIL-10+ Bregs, CD4+Foxp3+ Tregs, CD4+CXCR5+Foxp3+ follicular regulatory T (TFR) cells in CHB or CHC patients.
Increased numbers of CD5+CD19+CD1dhighIL-10+ Bregs, CD4+Foxp3+ Tregs, CD4+CXCR5+Foxp3+ follicular regulatory T (TFR) cells in CHB or CHC patients.
复制标题
DOI：
10.1186/s12967-014-0251-9
复制
发表时间：
2014-09-09
影响因子：
7.4
通讯作者：
Jiang Y
中科院分区：
文献类型：
--
作者：
Wang L;Qiu J;Yu L;Hu X;Zhao P;Jiang Y
IL-10+调节性B细胞（Bregs）、CD4+Foxp3+调节性T细胞（Tregs）和CD4+CXCR5+Foxp3+滤泡调节性T细胞（TFR）调节感染性疾病的进展。本研究旨在研究这些细胞在中国人群中如何与慢性乙型肝炎（CHB）和慢性丙型肝炎（CHC）的发展相关。用流式细胞术检测了31例CHC、58例CHB和22例健康对照（HC）的循环IL-10+ Bregs、Tregs和TFR细胞的数量。分析了这些细胞与临床指标的潜在关联。CHB患者CD5+CD19+CD1dhighIL-10+ Bregs、Tregs、TFR细胞数量及血清IL-10、IFN-γ、IL-2水平，CHC患者IL-10、IFN-γ水平均显著高于HC患者（p < 0.05）。此外，循环IL-10+ Bregs的数量和血清IL-10水平与HBeAg−CHB患者的血清HBV DNA和ALT水平以及CHC患者的HCV RNA和ALT水平呈正相关，而不检测其他细胞因子。此外，循环TFR细胞的数量与CHB患者的血清HBV DNA和ALT水平以及CHC患者的HCV RNA和ALT水平呈正相关。在CHB和CHC患者中，循环IL-10+ Bregs和TFR细胞数量的增加与病毒根除不良和肝损伤有关。此外，血清IL-10水平与肝耀斑有关。
IL-10+ regulatory B (Bregs), CD4+Foxp3+ regulatory T (Tregs), and CD4+CXCR5+Foxp3+ follicular regulatory T (TFR) cells regulate the progression of infection disease. This study aimed at examining how those cells associated with the development of chronic hepatitis B (CHB) and chronic hepatitis C (CHC) in a Chinese population. The numbers of circulating IL-10+ Bregs, Tregs and TFR cells in 31 CHC, 58 CHB patients and 22 healthy controls (HC) were examined by flow cytometry. The potential association of those cells with clinical measures was analyzed. The numbers of CD5+CD19+CD1dhighIL-10+ Bregs, Tregs and TFR cells and the levels of serum IL-10, IFN-γ and IL-2 in the CHB, and IL-10 and IFN-γ in the CHC patients were significantly higher than that in the HC (p < 0.05). Furthermore, the numbers of circulating IL-10+ Bregs and the levels of serum IL-10, but not other cytokines tested were positively correlated with the levels of serum HBV DNA and ALT in the HBeAg− CHB patients as well as HCV RNA and ALT in CHC patients. Additionally, the numbers of circulating TFR cells were positively correlated with the levels of serum HBV DNA and ALT in the CHB patients as well as HCV RNA and ALT in the CHC patients. Increased numbers of circulating IL-10+ Bregs and TFR cells are associated with poor virus eradication and liver injury in CHB and CHC patients. Furthermore, the levels of serum IL-10 is associated with the hepatic flares.
登录
查看更多内容
影响因子：
6.1
作者：
Li Xiao-dong;Wang Lin;Xu Dong-ping
通讯作者：
Xu Dong-ping
影响因子：
4.1
作者：
Gao B
通讯作者：
Gao B
影响因子：
8
作者：
Hong, F;Kim, WH;Gao, B
通讯作者：
Gao, B
影响因子：
6.7
作者：
Cardoso, Ana-Carolina;Carvalho-Filho, Roberto J.;Marcellin, Patrick
通讯作者：
Marcellin, Patrick
DOI：
10.4049/jimmunol.1103139
发表时间：
2012-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Das A;Ellis G;Pallant C;Lopes AR;Khanna P;Peppa D;Chen A;Blair P;Dusheiko G;Gill U;Kennedy PT;Brunetto M;Lampertico P;Mauri C;Maini MK
通讯作者：
Maini MK