Clinical application of four-dimensional noise reduction filtering with a similarity algorithm in dynamic myocardial computed tomography perfusion imaging
Clinical application of four-dimensional noise reduction filtering with a similarity algorithm in dynamic myocardial computed tomography perfusion imaging
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DOI：
10.1007/s10554-020-01878-6
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发表时间：
2020-05-12
影响因子：
2.1
通讯作者：
Mochizuki, Teruhito
中科院分区：
文献类型：
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作者：
Kouchi, Takanori;Tanabe, Yuki;Mochizuki, Teruhito
目的评价基于相似算法的四维降噪滤波(4D-SF)对动态心肌CT灌注成像(CTP)图像质量和血流动力学参数的影响。入选68例接受动态心肌CTP评价冠状动脉病变的患者。动态CTP采用320排CT，低管电压扫描(80kVP)。分别使用迭代重建(IR)和IR和4D-SF相结合的方法重建了两个不同的动态CTP数据集。评价定性(5级)和定量图像质量评分，并量化CT心肌血流量(CT-MBF)。并对两种不同CTP图像的结果进行比较。用IR和4D-SF重建的CTP图像的质量明显高于单独用IR重建的图像质量(噪声分数：4.7比3.4，p<；0.05)。用IR和4D-SF重建的CTP图像的信噪比(SNR)和对比噪声比(CNR)显著高于单独使用IR的CTP图像(SNR：20.6比9.7；CNR：7.9比3.9；p<；0.05)。两组CTP图像的平均CTMBF值分别为3.01mL/g/min和3.03mL/g/min，P=0.1081。4D-SF在低管电位动态心肌CTP成像中，在不改变CT-MBF定量的前提下，结合IR可提高图像质量。
We aimed to evaluate the effects of four-dimensional noise reduction filtering using a similarity algorithm (4D-SF) on the image quality and hemodynamic parameter of dynamic myocardial computed tomography perfusion (CTP). Sixty-eight patients who underwent dynamic myocardial CTP for the assessment of coronary artery disease were enrolled. Dynamic CTP was performed using a 320-row CT with low tube voltage scan (80 kVp). Two different datasets of dynamic CTP were reconstructed using iterative reconstruction (IR) alone and a combination of IR and 4D-SF. Qualitative (5-grade scale) and quantitative image quality scores were assessed, and the CT-derived myocardial blood flow (CT-MBF) was quantified. These results were compared between the two different CTP images. The qualitative image quality in CTP images reconstructed with IR and 4D-SF was significantly higher than that with IR alone (noise score: 4.7 vs. 3.4, p < 0.05). The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in CTP images reconstructed with IR and 4D-SF were significantly higher than those with IR alone (SNR: 20.6 vs. 9.7; CNR: 7.9 vs. 3.9, respectively; p < 0.05). There was no significant difference in mean CT-MBF between the two sets of CTP images (3.01 vs. 3.03 mL/g/min, p = 0.1081). 4D-SF showed incremental value in improving image quality in combination with IR without altering CT-MBF quantification in dynamic myocardial CTP imaging with a low tube potential.