NITRIC OXIDE-RELATED AGENTS ALTER ALCOHOL-WITHDRAWAL IN MALE-RATS
NITRIC OXIDE-RELATED AGENTS ALTER ALCOHOL-WITHDRAWAL IN MALE-RATS
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DOI：
10.1111/j.1530-0277.1995.tb01492.x
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发表时间：
1995-02-01
影响因子：
3.2
通讯作者：
CICERO, TJ
中科院分区：
文献类型：
--
作者：
ADAMS, ML;SEWING, BN;CICERO, TJ
已有证据支持一氧化氮（NO）部分介导吗啡依赖表达的假设。为了研究NO相关的药物是否也影响酒精依赖的表达，成年雄性大鼠长期接受。酒精在停止酒精给药后，用NO合酶（NOS）抑制剂N-G-硝基-L-精氨酸甲酯（NAME）或NO供体硝酸异山梨酯（ISDN）治疗后观察到戒断体征。戒断严重程度主要基于震颤、强直、多动以及自发性和听源性惊厥的存在和强度。在酒精戒断期间注射NOS抑制剂NAME（10-100 mg/kg）可显著抑制戒断严重程度，降低多动、震颤和强直体征的强度，但不影响惊厥的发生。NO供体ISDN（30 mg/kg）在酒精戒断期间给药显著增加了大多数戒断体征的严重程度。提示NO在酒依赖的某些方面有表达。
Evidence has been reported supporting the hypothesis that nitric oxide (NO) partially mediates the expression of morphine dependence. To examine whether NO-related agents also affect the expression of alcohol dependence, adult male rats were treated chronically with. alcohol. Upon withdrawal of alcohol administration, abstinence signs were observed after treatment with a NO synthase (NOS) inhibitor, N-G-nitro-L-arginine methyl ester (NAME), or a NO donor, isosorbide dinitrate (ISDN). Withdrawal severity was based primarily on the presence and intensity of tremors, rigidity, hyperactivity, and spontaneous and audiogenic convulsions. The NOS inhibitor, NAME (10-100 mg/kg), injected during alcohol withdrawal significantly inhibited withdrawal severity decreasing the intensity of signs of hyperactivity, tremors, and rigidity, but not affecting the occurrence of convulsions. The NO donor, ISDN (30 mg/kg), administered during alcohol withdrawal significantly increased the severity of most withdrawal signs. These results suggest that NO some aspects of the expression of alcohol dependence.