Nucleotide receptor signalling and the generation of reactive oxygen species.
Nucleotide receptor signalling and the generation of reactive oxygen species.
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DOI：
10.1007/s11302-006-9035-x
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发表时间：
2007-03
影响因子：
3.5
通讯作者：
Bertics, Paul J.
中科院分区：
文献类型：
--
作者：
Guerra, Alma N.;Gavala, Monica L.;Chung, Hun Sun;Bertics, Paul J.
关键词：
细胞外核苷酸水平升高出现在炎症、血小板脱颗粒和细胞损伤或溶解的部位。这些胞外核苷酸可以激活各种白细胞上的嘌呤能(核苷酸)受体，包括单核细胞、巨噬细胞、嗜酸性粒细胞和中性粒细胞。反过来，核苷酸受体的激活与细胞产生和释放多种炎症介质有关，包括超氧阴离子、一氧化氮和其他活性氧物种(ROS)。在本文中，我们将对细胞外核苷酸促进白细胞产生多种ROS的证据进行综述。此外，我们还将讨论核苷酸增强的ROS产生的几种潜在机制。这些机制的描述对于理解与核苷酸诱导的抗菌活性、细胞信号、细胞凋亡和病理学相关的过程非常重要。
Elevated levels of extracellular nucleotides are present at sites of inflammation, platelet degranulation and cellular damage or lysis. These extracellular nucleotides can lead to the activation of purinergic (nucleotide) receptors on various leukocytes, including monocytes, macrophages, eosinophils, and neutrophils. In turn, nucleotide receptor activation has been linked to increased cellular production and release of multiple inflammatory mediators, including superoxide anion, nitric oxide and other reactive oxygen species (ROS). In the present review, we will summarize the evidence that extracellular nucleotides can facilitate the generation of multiple ROS by leukocytes. In addition, we will discuss several potential mechanisms by which nucleotide-enhanced ROS production may occur. Delineation of these mechanisms is important for understanding the processes associated with nucleotide-induced antimicrobial activities, cell signalling, apoptosis, and pathology.
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