Third Epidemiological Analysis of Nasopharyngeal Carcinoma in the Central Region of Japan from 2006 to 2015
Third Epidemiological Analysis of Nasopharyngeal Carcinoma in the Central Region of Japan from 2006 to 2015
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DOI：
10.3390/cancers11081180
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发表时间：
2019-08-01
期刊：
影响因子：
5.2
通讯作者：
Fujieda, Shigeharu
中科院分区：
文献类型：
--
作者：
Kanno, Masafumi;Narita, Norihiko;Fujieda, Shigeharu
本研究旨在阐明日本中部地区2006-2015年间鼻咽癌(NPC)的发病率和临床转归，并与以往的报道进行比较。一项基于位于日本中部主岛中部地区的40家医院的医疗记录进行了回顾分析，这些医院的人口约为2266万人。这项研究的设计与之前在日本同一地区进行的两项鼻咽癌临床研究一致。我们招募了在该地区医院确诊的鼻咽癌患者，时间跨度为10年(2006-2015)，调查内容包括性别、年龄、原发部位、临床症状、病理、国际癌症控制联盟(UICC)分期、血清学检查、治疗和生存率。共有620名鼻咽癌患者被确认。2006年至2015年鼻咽癌标化发病率为0.27/10万人/年。这项研究与之前在日本同一地区进行的两项研究没有显著差异。所有患者的五年总生存率为75.9%，而I、II、III和IVA期患者的总生存率分别为97%、91%、79%和68%。本研究的鼻咽癌标化年发病率为0.27/10万人/年，相对较低且稳定。与之前的研究相比，在这十年中，所有鼻咽癌患者的五年总存活率都有了显著的提高。男性和女性鼻咽癌患者吸烟率分别为64.5%和18.8%，提示吸烟与鼻咽癌的发病有关。
The present study aimed to clarify the incidence and clinical outcomes of nasopharyngeal carcinoma (NPC) in the Chubu region of Japan from 2006 to 2015, compared with previous reports. A retrospective analysis was conducted based on medical records from 40 hospitals located in the Chubu region in the central Japanese main island, with a population of around 22.66 million individuals. This study was designed in line with to two previous clinical studies into NPC conducted in the same area of Japan. We recruited NPC patients diagnosed in hospitals across this area over a 10-year period (2006-2015) using a questionnaire about sex, age, primary site, clinical symptoms, pathology, Union for International Cancer Control (UICC) staging, serological exam, treatment, and survival. A total of 620 NPC patients were identified. The age-standardized incidence of NPC from 2006 to 2015 was 0.27 per 100,000 individuals per year. There were no significant differences between this study and the previous two studies conducted in the same area of Japan. The five-year overall survival rate for all patients was 75.9%, while those for patients with stages I, II, III, and IVA were 97%, 91%, 79%, and 68%, respectively. The age-standardized annual incidence of NPC in the present study was 0.27 per 100,000 individuals per year, which was relatively low and stable. The five-year overall survival rate for all NPC patients was significantly improved in this decade compared with previous studies. The smoking rates in male and female NPC patients were 64.5% and 18.8%, respectively, thereby suggesting the involvement of smoking in the incidence of NPC.