OBSERVATIONS ON 2 PLASMODIUM FALCIPARUM INFECTIONS WITH AN ABNORMAL RESPONSE TO CHLOROQUINE
OBSERVATIONS ON 2 PLASMODIUM FALCIPARUM INFECTIONS WITH AN ABNORMAL RESPONSE TO CHLOROQUINE
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DOI：
10.4269/ajtmh.1961.10.5
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发表时间：
1961-01-01
影响因子：
3.3
通讯作者：
LANIER, JE
中科院分区：
文献类型：
--
作者：
MOORE, DV;LANIER, JE
2例恶性疟原虫感染均发生在南美洲哥伦比亚。这两种感染都对那里的氯喹治疗无效。第1例患者接受了3个疗程的1.5 g氯喹，并在第1个疗程和第2个疗程后分别在12天和18天出现临床和寄生虫复发。在完成3d疗程后，以每日0.3g的剂量继续给药14天，在此期间血涂片保持阳性。3天疗程的硫酸奎宁（90格令）产生阴性血涂片，但17天后发生寄生虫复发。服用奎宁10天的疗程明显治愈了。第2天患者在第1个疗程氯喹后约20天出现临床和寄生虫复发;第2个疗程（2.1 g）后，继以伯氨喹14天疗程，在氯喹治疗完成后约21天观察到寄生虫血症复发伴轻微症状。服用奎宁10天的疗程明显治愈了。
The 2 infections of Plasmodium falciparum were acquired in Colombia, South America. Both infections failed to respond to chloroquine therapy administered there. The 1st patient received 3 further courses of 1.5 g of chloroquine and experienced clinical and parasitic relapses 12 and 18 days, respectively, after the 1st 2 courses. Upon completion of the 3d course, the drug was continued for 14 more days at a dosage of 0.3 g daily and blood smears remained positive during this period. A 3 day course of quinine sulfate (90 grains) produced negative blood smears, but a parasitic relapse occurred after 17 days. An apparent cure was effected by a 10 day course of quinine. The 2d patient experienced a clinical and parasitic relapse approximately 20 days after the 1st course of chloroquine; and after 2nd course (2.1 g) followed by a 14-day course of primaquine, a recurrence of parasitemia accompanied by minor symptoms approximately 21 days after the completion of the chloroquine therapy was observed. A 10 day course of quinine produced an apparent cure.