Seroepidemiology and molecular epidemiology of Kaposi's sarcoma-associated herpesvirus among Jewish population groups in Israel
Seroepidemiology and molecular epidemiology of Kaposi's sarcoma-associated herpesvirus among Jewish population groups in Israel
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DOI：
10.1093/jnci/93.3.194
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发表时间：
2001-02-07
影响因子：
10.3
通讯作者：
Boshoff, C
中科院分区：
文献类型：
--
作者：
Davidovici, B;Karakis, I;Boshoff, C
背景：以色列犹太人经典卡波西肉瘤的发病率是发达国家中最高的。卡波西肉瘤相关疱疹病毒（KSHV或人类疱疹病毒8）与卡波西肉瘤有因果关系，关于中东地区KSHV的流行情况或地中海国家的传播方式知之甚少。研究方法：从1992年至1995年，血清中获得了1648名成年人谁曾检测阳性的B型肝炎病毒（HBV）表面抗原20年前在献血，血清也获得了2403他们的家庭成员。使用间接免疫荧光试验检测所有血清中的抗KSHV抗体。为分析各种因素对HBV阳性队列及其家庭感染KSHV风险的影响，采用Logistic回归聚类分析和广义估计方程。所有统计检验均为双侧检验。结果如下：在家庭成员中，KSHV抗体阳性率为9.9%（95%可信区间[CI] = 8.7%~ 11.1%），在既往B型肝炎检测阳性的献血员中，KSHV抗体阳性率为22%（95% CI = 19.9%~ 24.1%）。发现夫妻双方KSHV检测阳性的最重要的风险因素是他们自己的出生地和配偶的血清阳性。对于一个孩子测试呈阳性，最重要的风险因素是母亲血清阳性。结论：KSHV在以色列犹太人中的粗患病率为9.9%，KSHV在所研究的家庭中传播的重要途径是配偶对配偶和母亲对子女，KSHV在以色列所有种族的犹太人中的存在以及报告的卡波西肉瘤的高发病率表明，KSHV在主要散居之前被引入犹太人中。
Background: The incidence of classic Kaposi's sarcoma among Jews in Israel is among the highest in the developed world. Kaposi's sarcoma-associated herpesvirus (KSHV or human herpesvirus 8) is causally linked to Kaposi's sarcoma, Very little is known about the prevalence of KSHV in the Middle East or about the modes of transmission in Mediterranean countries. Methods: From 1992 through 1995, sera were obtained from 1648 adults who had tested positive for hepatitis B virus (HBV) surface antigen 20 years earlier at blood donations; sera were also obtained from 2403 of their family members. All sera were tested for anti-KSHV antibodies with the use of an indirect immunofluorescence assay. To analyze the effects of various factors on the risk of KSHV infection for both the HBV-positive cohort and their families, logistic regression for cluster data and generalized estimating equations were used. All statistical tests were two-sided. Results: Among family members, the seroprevalence of antibodies against KSHV was 9.9% (95% confidence interval [CI] = 8.7% to 11.1%); among the former blood donors who had tested positive for hepatitis B, it was 22% (95% CI = 19.9% to 24.1%), Overall, the best predictor of KSHV status was the place of birth. The most important risk factors found for both husband and wife to test KSHV positive were their own places of birth and their spouse's seropositivity. For a child to test positive, the most important risk factor was maternal seropositivity. Conclusions: The crude prevalence rate of KSHV among the Jewish population in Israel is 9.9%, Important routes of KSHV transmission in the families studied are spouse to spouse and mother to child, The presence of KSHV in Jews in Israel of all ethnic origins and their high incidence of reported Kaposi's sarcoma suggest that KSHV was introduced into the Jewish population prior to the major Diaspora.