Age at menarche, abnormal glucose tolerance and type 2 diabetes mellitus: The Rancho Bernardo Study
Age at menarche, abnormal glucose tolerance and type 2 diabetes mellitus: The Rancho Bernardo Study
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DOI：
10.1080/13697130500062688
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发表时间：
2005-03-01
期刊：
影响因子：
2.8
通讯作者：
Barrett-Connor, E
中科院分区：
文献类型：
--
作者：
Saquib, N;Kritz-Silverstein, D;Barrett-Connor, E
目的探讨绝经后妇女月经初潮年龄与糖耐量异常（AGT）和2型糖尿病的关系。1989年收集了关于初潮年龄的资料。糖尿病状态以WHO 1999标准为基础，AGT以空腹血糖受损（IFG）或糖耐量受损（IGT）为标准。月经初潮< 1.2年者占14.5%，12-15年者占78.9%，≥ 16年者占6.6%。年龄和体重指数（BMI）预测AGT（分别为p < 0.001，p = 0.003），而年龄、BMI和糖尿病家族史预测2型糖尿病（分别为p < 0.001，p < 0.001，p = 0.02）。多项式逻辑回归显示初潮与AGT或2型糖尿病风险无关。然而，在线性回归中，初潮年龄较大与空腹（p=0.01）和激发后血糖（p=0.03）较低相关。协变量，尤其是BMI，削弱了这些关联，尽管月经初潮≥ 16年的女性与月经初潮< 1.2年的女性相比，挑战后血糖（0.86 mmol/l，p = 0.05）和空腹血糖（0.26 mmol/l，p = 0.11）仍然较低。初潮年龄晚与禁食和攻毒后腹泻呈负相关。肥胖可能介导所观察到的关联。
Objective We examined the association of age at menarche with risk of abnormal glucose tolerance (AGT) and type 2 diabetes in postmenopausal women.Methods Participants were 997 women aged 50-92 years who had a clinic visit in 1984-87, when reproductive and diabetes history were recorded, and an oral glucose tolerance test administered. Information on age at menarche was collected in 1989. Diabetes status was based on WHO 1999 criteria, and AGT on having impaired fasting glucose (IFG) or impaired glucose tolerance (IGT).Results The average age was 69.5 years; 12.5% had diabetes and 29.8% had AGT. Menarche was < 1.2 years in 14.5%, 12-15 years in 78.9% and ≥ 16 years in 6.6%. Age and body mass index (BMI) predicted AGT (p < 0.001, p = 0.003, respectively), while age, BMI and family history of diabetes predicted type 2 diabetes (p < 0.001, p < 0.001, p = 0.02, respectively). Polynomial logistic regression showed no association of menarche with AGT or type 2 diabetes risk. In linear regressions, however, older age at menarche was associated with lower fasting (p=0.01) and post-challenge plasma glucose (p=0.03). Covariates, especially BMI, weakened these associations, although women with menarche ≥ 16 years still had lower post-challenge (0.86 mmol/l, p = 0.05) and fasting glucose (0.26 mmol/l, p = 0.11) than those with menarche < 1.2 years.Conclusions Age at menarche was not associated with AGT or type 2 diabetes risk. Late age at menarche was inversely associated with fasting and post-challenge glycemia. Obesity may mediate the observed associations.