A 3-D model of membrane specializations between human auditory spiral ganglion cells
A 3-D model of membrane specializations between human auditory spiral ganglion cells
复制标题
人类听觉螺旋神经节细胞膜特化的 3D 模型
DOI：
10.1023/a:1015628831641
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
H. Rask
中科院分区：
文献类型：
--
作者：
S. Tylstedt;H. Rask
在正常人耳蜗细胞簇的两个大螺旋神经节细胞（1 型细胞）之间制作了细胞膜接触区域的三维模型。新固定的耳蜗在颅底手术中被移除，进行处理并切片以进行超微结构分析。从神经细胞密度高、细胞簇众多的顶端部分制备400个连续的连续薄片。细胞簇被定义为两个或多个神经细胞体的聚集体，周围环绕着常见的雪旺细胞。在相邻细胞缺乏分离的雪旺细胞层（间隙）的地方，神经节细胞膜（ephapse）之间的直接物理接触是可能的。选择一个这样的间隙，并在 90 个连续截面中的 57 个截面中进行观察。在 36 个切片中观察到的膜特化主要属于三种不同类型，即：(1) 对称、(2) 不对称和 (3) 不对称质膜下。这些膜特化的功能特性仍然未知。在两个细胞膜之一或另一个上观察到不对称密度。制作了基于连续薄片的图形模型来说明间隙区域。表面膜特化形成大小不同的小盘状区域，最大的尺寸为 3 × 2 μm。人们推测，人类螺旋神经节细胞之间的这些独特结构（在其他物种中尚未观察到）是否可能构成交互式电紧张或触觉传输途径。这些可以位于低频区域并且可以增加与语音编码相关的可塑性和信号敏锐度。
A three-dimensional model of the cell membrane contact area was made between two large spiral ganglion cells (type 1 cells) from a cell cluster in a normal human cochlea. The freshly fixed cochlea had been removed during skull base surgery, processed, and sectioned for ultrastructural analysis. 400 consecutive serial thin sections were prepared from the apical portion where the nerve cell density is high and cell clusters are numerous. A cell cluster is defined as a conglomerate of two or more nerve cell bodies, surrounded by common Schwann cells. Direct physical contact between ganglion cell membranes (ephapse) was possible, in places where adjacent cells lacked a separating Schwann cell layer (gaps). One such gap was selected, and observed in 57 of 90 consecutive sections. Membrane specializations, observed in 36 sections, were found to be of principally three different types namely: (1) symmetrical, (2) asymmetrical, and (3) asymmetrical subplasmalemmal. The functional properties of these membrane specializations are still unknown. Asymmetrical densities were seen on one or other of the two cell membranes. A graphic model based on serial thin sections was made to illustrate the gap area. Superficially membrane specializations were seen to form small disk-like areas varying in size, the largest measuring 3 × 2 μm. It is speculated whether these unique formations between human spiral ganglion cells, which have not been observed in other species, may constitute interactive electrotonic or ephaptic transmission pathways. These may be in the low-frequency region and may increase plasticity and signal acuity related to the coding of speech.
螺旋神经节中的突触和突触。
DOI：
--
发表时间：
1987
期刊：
Acta oto-laryngologica. Supplementum
影响因子：
--
作者：
Kimura,RS;Bongiorno,CL;Iverson,NA
通讯作者：
Iverson,NA