"Molecular trinity" for soft nanomaterials: Integrating nucleobases, amino acids, and glycosides to construct multifunctional hydrogelators.
"Molecular trinity" for soft nanomaterials: Integrating nucleobases, amino acids, and glycosides to construct multifunctional hydrogelators.
复制标题
DOI：
10.1039/c2sm06920b
复制
发表时间：
2012-03-14
期刊：
影响因子：
3.4
通讯作者：
Xu B
中科院分区：
文献类型：
--
作者：
Li X;Kuang Y;Xu B
本重点介绍了由核碱基、氨基酸和糖苷（即分子三位一体）或核碱基和氨基酸（即核肽）组成的水凝胶剂的开发。这些新型小分子水凝胶剂在水中自组装形成稳定的超分子纳米纤维/水凝胶，并表现出有用的生物特性（例如生物相容性、生物稳定性以及结合和运输 DNA 到活细胞中的能力）。这里讨论的方法不仅提供了开发作为纳米药物形式的软生物材料的新策略，而且还通过调节来自生物体中使用的三种基本构件的非共价相互作用，有助于理解水中的分子自组装。
This highlight introduces the development of hydrogelators consisting of nucleobases, amino acids, and glycosides (i.e., molecular trinity), or nucleobases and amino acids (i.e., nucleopeptides). These novel small molecule hydrogelators self-assemble in water to form stable supramolecular nanofibers/hydrogels and exhibit useful biological properties (e.g., biocompatibility, biostability, and the ability to bind and transport DNA into live cells). The approach discussed here not only provides a new strategy to develop soft biomaterials as a form of nanomedicines, but also contributes to the understanding of molecular self-assembly in water by modulating the non-covalent interactions derived from the three basic building blocks used in living organisms.