Phytochemical and pharmacological studies on Orthosiphon stamineus Benth. (Lamiaceae) hydroalcoholic extracts
Phytochemical and pharmacological studies on Orthosiphon stamineus Benth. (Lamiaceae) hydroalcoholic extracts
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DOI：
10.1016/s0731-7085(03)00227-9
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发表时间：
2003-09-15
影响因子：
3.4
通讯作者：
Gocan, S
中科院分区：
文献类型：
--
作者：
Olah, NK;Radu, L;Gocan, S
本文对草管根的主要化学成分进行了研究。叶和提取物是具有抗氧化活性的多酚：多甲氧基化的类黄酮和咖啡酸衍生物。从植物化学和药理学角度对两种不同酒精浓度的酊剂进行了研究。采用高效液相色谱法对主要多酚类物质进行了定性和定量分析。保留参数和紫外-可见光谱的标准品和那些分离的化合物的比较进行鉴定的咖啡酸，菊苣酸和迷迭香酸，分别为sineself和eupatorine。采用外标法定量。通过大鼠实验，比较了所研究的酊剂的利尿、排盐和排尿酸作用。(C)2003 Elsevier Science B. V.保留所有权利。
The main components of Orthosiphon stamineus Benth. leaves and extracts are the pharmacologically active polyphenols: the polymethoxylated flavonoids and the caffeic acid derivatives. Two tinctures, having different alcohol concentration, were studied from phytochemical and pharmacological point of view. The main polyphenols were identified and quantitatively determined by HPLC. Comparison of the retention parameters and UV-Vis spectra of standards and those of the separated compounds performed the identification of caffeic-, cichoric- and rosmarinic acids, respectively, of sinesetine and eupatorine. The quantitative determination was performed by external standard method. The diuretic, saluretic and uricosuric actions of the studied tinctures were compared by experiments on rats. (C) 2003 Elsevier Science B.V. All rights reserved.