5'-UTR RNA G-quadruplexes: translation regulation and targeting.
5'-UTR RNA G-quadruplexes: translation regulation and targeting.
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DOI：
10.1093/nar/gks068
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发表时间：
2012-06
影响因子：
14.9
通讯作者：
Balasubramanian S
中科院分区：
文献类型：
--
作者：
Bugaut A;Balasubramanian S
MRNAs非翻译区的RNA结构影响基因表达的转录后调控。这一领域的大部分知识依赖于典型的双链RNA元件。最近，我们对富含鸟嘌呤(G)的核酸序列的理解有了相当大的进步，这些序列形成了四链结构，称为G-四链体。虽然大部分研究都集中在DNA G-四链体上，但最近对RNA G-四链体的兴趣迅速兴起，特别是在mRNAs的5‘-UTRs上。总而言之，这些研究表明，RNAG-四联体存在于许多基因的5‘-UTRs中，包括临床上感兴趣的基因，并且这些结构元素可以影响翻译。本文综述了5‘-UTRRNA G-四链介导的翻译调控的研究进展。它包括计算分析、无细胞、基于细胞的和化学生物学研究，这些研究试图阐明RNAG-四联体在帽依赖和非依赖的mRNA翻译调控中的作用。我们还讨论了已经涉及的蛋白质反式作用因子以及这些RNA基序作为小分子靶标的证据。最后，我们对5‘-UTRRNA G-四链介导的翻译调控领域未来的挑战进行了展望。
RNA structures in the untranslated regions (UTRs) of mRNAs influence post-transcriptional regulation of gene expression. Much of the knowledge in this area depends on canonical double-stranded RNA elements. There has been considerable recent advancement of our understanding of guanine(G)-rich nucleic acids sequences that form four-stranded structures, called G-quadruplexes. While much of the research has been focused on DNA G-quadruplexes, there has recently been a rapid emergence of interest in RNA G-quadruplexes, particularly in the 5′-UTRs of mRNAs. Collectively, these studies suggest that RNA G-quadruplexes exist in the 5′-UTRs of many genes, including genes of clinical interest, and that such structural elements can influence translation. This review features the progresses in the study of 5′-UTR RNA G-quadruplex-mediated translational control. It covers computational analysis, cell-free, cell-based and chemical biology studies that have sought to elucidate the roles of RNA G-quadruplexes in both cap-dependent and -independent regulation of mRNA translation. We also discuss protein trans-acting factors that have been implicated and the evidence that such RNA motifs have potential as small molecule target. Finally, we close the review with a perspective on the future challenges in the field of 5′-UTR RNA G-quadruplex-mediated translation regulation.
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影响因子：
3.2
作者：
Bugaut A;Rodriguez R;Kumari S;Hsu ST;Balasubramanian S
通讯作者：
Balasubramanian S
DOI：
10.1083/jcb.136.4.761
发表时间：
1997-02-24
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bashkirov VI;Scherthan H;Solinger JA;Buerstedde JM;Heyer WD
通讯作者：
Heyer WD
影响因子：
4.5
作者：
Babendure, JR;Babendure, JL;Tsien, RY
通讯作者：
Tsien, RY
影响因子：
56.9
作者：
Azzalin, Claus M.;Reichenbach, Patrick;Lingner, Joachim
通讯作者：
Lingner, Joachim
RNA 双链体-四链体连接的 FMRP RGG 肽识别的结构功能研究。
影响因子：
16.8
作者：
Anh Tuan Phan;Kuryavyi, Vitaly;Darnell, Jennifer C.;Serganov, Alexander;Majumdar, Ananya;Ilin, Serge;Raslin, Tanya;Polonskaia, Anna;Chen, Cynthia;Clain, David;Darnell, Robert B.;Patel, Dinshaw J.
通讯作者：
Patel, Dinshaw J.