BISMUTH SUBSALICYLATE REDUCES PEPTIC INJURY OF THE ESOPHAGUS IN RABBITS
BISMUTH SUBSALICYLATE REDUCES PEPTIC INJURY OF THE ESOPHAGUS IN RABBITS
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DOI：
10.1136/gut.31.1.11
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发表时间：
1990-01-01
期刊：
影响因子：
24.5
通讯作者：
SCHWEITZER, EJ
中科院分区：
文献类型：
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作者：
TAY, HP;CHAPARALA, RC;SCHWEITZER, EJ
在体内灌注的兔食管炎模型中测试碱式水杨酸铋预防胃蛋白酶引起的粘膜损伤的能力。根据损伤前治疗方案和损伤后治疗方案评估治疗效果。通过测量H+、K+和葡萄糖的通量率来评价食管粘膜屏障功能。由几名独立观察员通过粘膜的大体和显微镜检查确定食管炎的程度。 结果表明，在两种治疗方案下，次水杨酸铋显着减少胃蛋白酶诱导的粘膜屏障破坏，以及形态学变化。暴露于胃蛋白酶后给予次水杨酸铋也发现以剂量依赖性方式保护免受形态学损伤。体外实验表明，次水杨酸铋通过与胃蛋白酶相互作用而不是与胃蛋白酶底物相互作用来抑制胃蛋白酶的蛋白水解作用。我们的结论是，次水杨酸铋可以保护食管粘膜对消化道损伤，可能是通过灭活胃蛋白酶。
Bismuth subsalicylate was tested in an in vivo perfused rabbit model of oesophagitis for its ability to prevent the mucosal injury caused by pepsin. Treatment efficacy was assessed under both a treatment-before-injury protocol and a treatment-after-injury protocol. Oestophageal muscosal barrier function was evaluated by measuring flux rates of H+, K+, and glucose. The degree of oesophagitis was determined by gross and microscopic examination of the mucosa by several independent observers. Results showed that under both treatment protocols, bismuth subsalicylate significantly reduced the pepsin induced disruption of the mucosal barrier, as well as the morphologic changes. Bismuth subsalicylate when given after exposure to pepsin was also found to protect against the morphologic injury in a dose dependent manner. Experiments in vitro suggested that bismuth subsalicylate inhibits the proteolytic action of pepsin by interacting with pepsin, rather than with the pepsin substrate. We conclude that bismuth subsalicylate can protect the oesophageal mucosa against peptic injury, probably through inactivation of pepsin.