Cytomorphologic Features of Primary Anaplastic Large Cell Lymphoma of the Psoas Muscle: A Case Report and Literature Review
Cytomorphologic Features of Primary Anaplastic Large Cell Lymphoma of the Psoas Muscle: A Case Report and Literature Review
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DOI：
10.1002/dc.21174
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发表时间：
2010-03-01
影响因子：
1.3
通讯作者：
Yang, Jack
中科院分区：
文献类型：
--
作者：
Recavarren, Rosemary A.;Yang, Jack
Ki-1(CD30)阳性间变性大细胞淋巴瘤(ALCL)是一种罕见的恶性肿瘤，原发骨骼肌Ki-1CD30阳性的ALCL是一种更为罕见的事件，文献报道很少，仅有一些报道有细胞形态学特征。83岁妇女，腰大肌细针抽吸(FNA)，涂片显示以解聚的大多形细胞为主，细胞核呈低染，分叶状，常有多核形成，核仁突出，细胞亚群呈空泡化，细胞质空泡化，未发现淋巴腺小体恶性细胞倾向于转移性黑色素瘤和低分化癌。原发腰大肌Ki-1(CD30)阳性，间变性大细胞淋巴瘤激酶(ALK)染色阴性的ALCL上皮样肿瘤的细胞学特征，肉瘤、黑色素瘤和其他淋巴瘤虽然罕见，但在肌肉肿瘤的FNA上遇到松散的多形性恶性细胞时，ALCL应该是一个诊断考虑因素。
Ki-1 (CD30) positive anaplastic large cell lymphoma (ALCL) is all uncommon malignancy, which may present with nodal as well as extra-nodal disease Primary skeletal muscle Ki-1 CD30 positive ALCL is all even rarer event with few cases reported in the literature and only some with published cytomorphologic features An 83-Year-old woman underwent a fine needle aspiration (FNA) of a psoas muscle mass Smears demonstrated a predominantly discohesive population of large pleomorphic cells The nuclei were hypechromatic and lobulated with often multinucleation Nucleoli were prominent lit a subset of cells Cytoplasmic vacuolization was also present No lympho-glandular bodies were identified A cytodiagnosis of malignant cells favoring metastatic melanoma vs poorly differentiated carcinoma was rendered Morphologic and immunohistochemical features later revealed a primary psoas muscle Ki-1 (CD30) positive ALCL with negative staining for anaplastic large cell lymphoma kinase (ALK) Cytologic features of ALCL mimic epithelial neoplasms, sarcomas, melanoma and other lymphomas Although rare, ALCL should be a diagnostic consideration when discohesive pleomorphic malignant cells are encountered on FNA of a muscle neoplasm Diagn Cytopathol 2010, 38 208-212 (C) 2009 Wiley-Liss, Inc