Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution.
Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution.
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小鼠外周淋巴器官中新型细胞类型的鉴定。 I.形态，定量，组织分布。
DOI：
10.1084/jem.137.5.1142
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发表时间：
1973-05-01
影响因子：
15.3
通讯作者：
Cohn, Z A
中科院分区：
文献类型：
--
作者：
Steinman, R M;Cohn, Z A
在从小鼠外周淋巴器官（脾、淋巴结、派伊尔集合淋巴结）制备的贴壁细胞群中鉴定了一种新的细胞类型。虽然存在于少数（总有核细胞的0.1-1.6%），细胞具有独特的形态特征。核大，可伸缩，形状扭曲，含有小核仁（通常为两个）。丰富的细胞质排列在不同长度和宽度的过程中，并含有许多大的球形线粒体。在活的状态下，细胞经历特征性的运动，并且与巨噬细胞不同，细胞似乎不参与主动的内吞作用。树突状细胞这个术语是为这种新的细胞类型提出的。
A novel cell type has been identified in adherent cell populations prepared from mouse peripheral lymphoid organs (spleen, lymph node, Peyer's patch). Though present in small numbers (0.1–1.6% of the total nucleated cells) the cells have distinct morphological features. The nucleus is large, retractile, contorted in shape, and contains small nucleoli (usually two). The abundant cytoplasm is arranged in processes of varying length and width and contains many large spherical mitochondria. In the living state, the cells undergo characteristic movements, and unlike macrophages, do not appear to engage in active endocytosis. The term, dendritic cell, is proposed for this novel cell type.