Docosahexaenoic acid (DHA), a fundamental fatty acid for the brain: New dietary sources
Docosahexaenoic acid (DHA), a fundamental fatty acid for the brain: New dietary sources
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DOI：
10.1016/j.plefa.2017.08.001
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发表时间：
2017-09-01
影响因子：
3
通讯作者：
Valenzuela, Alfonso
中科院分区：
文献类型：
--
作者：
Echeverria, Francisca;Valenzuela, Rodrigo;Valenzuela, Alfonso
二十二碳六烯酸(C22：6N-3，DHA)是一种海洋来源的长链多不饱和脂肪酸，对神经系统的形成和功能至关重要，特别是对人类的大脑和视网膜。DHA在人类进化过程中起着非常重要的作用，主要作用于大脑的生长和发育。目前，DHA被认为是怀孕和哺乳期间的关键营养物质，因为他们在生命早期积极参与神经系统的发育。DHA及其衍生物之一被称为神经保护素D-1(NPD-1)，对脑老化、神经退行性疾病和脑缺血再灌注后造成的损伤具有神经保护作用。本文讨论了DHA在人脑中的重要性，因为它与组织的发育和作为神经保护剂有关。它还包括了对如何向人们供应这种贵重脂肪酸的批判性观点。
Docosahexaenoic acid (C22: 6n-3, DHA) is a long-chain polyunsaturated fatty acid of marine origin fundamental for the formation and function of the nervous system, particularly the brain and the retina of humans. It has been proposed a remarkable role of DHA during human evolution, mainly on the growth and development of the brain. Currently, DHA is considered a critical nutrient during pregnancy and breastfeeding due their active participation in the development of the nervous system in early life. DHA and specifically one of its derivatives known as neuroprotectin D-1 (NPD-1), has neuroprotective properties against brain aging, neurodegenerative diseases and injury caused after brain ischemia-reperfusion episodes. This paper discusses the importance of DHA in the human brain given its relevance in the development of the tissue and as neuroprotective agent. It is also included a critical view about the ways to supply this noble fatty acid to the population.