A new pyrrolizidine alkaloid and other constituents from the roots of Ligularia achyrotricha (Diels) Ling
A new pyrrolizidine alkaloid and other constituents from the roots of Ligularia achyrotricha (Diels) Ling
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一种新的吡咯里西啶生物碱和来自橐吾根的其他成分
DOI：
10.1016/j.phytol.2012.05.009
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发表时间：
2012-09-01
影响因子：
1.7
通讯作者：
Gao, Kun
中科院分区：
文献类型：
--
作者：
Hua, Lei;Chen, Jia;Gao, Kun
粗毛连(Ligularia achyrotricha(Diels)Ling)是传统的藏药。Ligulachyroine A(1)是一个新的十二元大环吡咯里西定生物碱，其酮基位于C-3，羟基位于C-8。特别值得注意的是，1的结构很少出现在迄今报道的任何其他天然存在的十二元大环吡咯里西丁生物碱中。3个已知的木脂素(2-4)和8个已知的针叶和芥子醇衍生物(5-12)也在本种中得到。通过对它们的红外光谱、质谱图和核磁共振谱的分析，确定了它们的结构。化合物1对HL-60和SMMC-7721细胞具有中等活性。皇冠版权所有(C)2012欧洲植物化学学会。爱思唯尔出版公司版权所有。
Ligularia achyrotricha (Diels) Ling has been used as a traditional Tibetan herbal medicine. Ligulachyroine A (1), a new twelve-membered macrocyclic pyrrolizidine alkaloid with a ketonic group located at C-3 and an hydroxy group linked at C-8, was isolated from the roots of L. achyrotricha. It is particularly noteworthy that the structure of 1 rarely appears in any other naturally occurring twelve-membered macrocyclic pyrrolizidine alkaloid reported to date. Three known lignans (2-4) and eight known coniferyl and sinapyl alcohol derivatives (5-12) were also obtained in this species. Their structures were elucidated through a careful analysis of their IR, MS, and NMR spectra. Compound 1 exhibited moderate activity against HL-60 and SMMC-7721 cells. Crown Copyright (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.