Body composition in Spinocerebellar ataxia type 3 and 10 patients: Comparative study with control group.
Body composition in Spinocerebellar ataxia type 3 and 10 patients: Comparative study with control group.
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DOI：
10.1080/1028415x.2018.1469282
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发表时间：
2020-01
影响因子：
3.6
通讯作者：
Teive HAG
中科院分区：
文献类型：
--
作者：
Leite CMBA;Schieferdecker MEM;Frehner C;Munhoz RP;Ashizawa T;Teive HAG
脊髓小脑共济失调（SCA）是一组神经退行性遗传疾病，其特征是运动障碍，可影响营养状况和身体组成。本研究旨在评估SCA 3和SCA 10患者的身体组成。对46名SCA 3和SCA 10患者和76名对照者进行人体测量评估和生物电阻抗分析。在患者中，69.6%患有SCA 3，58.7%为女性。SCA 3患者的体脂百分比（%BF）分别显著低于对照组（15.0 ± 6.1 vs. 20.6 ± 7.1; p=0.014）和（22.4 ± 6.9 vs. 30.1 ± 6.0; p<0.001）。在女性中，SCA 3和SCA 10患者之间的%BF存在统计学显著差异（22.4 ± 6.9 vs. 32.4 ± 4.9; p<0.001）。男性和女性SCA 3患者的去脂体重（FFM）分别显著低于对照组[50.6 kg（46.9-54.7）vs.58.6 kg（52.6-63.9）; p=0.001]和[38.2 kg（35.1-42.6）vs.42.8 kg（39.7-46.1）; p=0.004]。男性SCA 10患者的FFM也低于对照组[51.2 kg（47.1-55.4）vs.（52.6-63.9）; p=0.008]。女性SCA 10患者的FFM显著高于对照组和SCA 3患者[分别为45.0 kg（43.3-45.6）vs. 42.8 kg（39.7-46.1）; p=0.004]和[45.0 kg（43.3-45.6）vs. 38.2 kg（35.1-42.6）; p=0.004]。SCA 3中疾病持续时间和肌肉质量（MM）之间存在中度相关性（-0.42），SARA（共济失调评估和评级量表）和MM之间存在弱相关性（-0.38）。在SCA 10中，这些变量之间没有显著相关性。女性SCA 3患者的身体成分变化较女性SCA 10患者多，主要与FFM有关。SCA 3和SCA 10患者需要营养随访，以尽量减少体室变化。
Spinocerebellar ataxias (SCAs) are a group of neurodegenerative genetic diseases characterized by movement disorders that can affect nutritional status and body composition. This study sought to assess body composition in SCA3 and SCA10 patients. Anthropometric assessments and bioelectric impedance analysis were performed in 46 SCA3 and SCA10 patients and 76 controls of both genders. Of the patients, 69.6% had SCA3 and 58.7% were women. SCA3 patients had significantly lower percentages of body fat (%BF) than controls (15.0 ± 6.1 vs. 20.6 ± 7.1; p=0.014) and (22.4 ± 6.9 vs. 30.1 ± 6.0; p<0.001), respectively. Among the women, there was a statistically significant difference in %BF between SCA3 and SCA10 patients (22.4 ± 6.9 vs. 32.4 ± 4.9; p<0.001). Male and female SCA3 patients had significantly lower fat-free mass (FFM) than controls [50.6 kg (46.9–54.7) vs.58.6 kg (52.6–63.9); p=0.001] and [38.2 kg (35.1–42.6) vs. 42.8 kg (39.7–46.1); p=0.004], respectively. Male SCA10 patients also had lower FFM than controls [51.2 kg (47.1–55.4) vs. (52.6–63.9); p=0.008]. Female SCA10 patients had significantly higher FFM than controls and SCA3 patients [45.0 kg (43.3–45.6) vs. 42.8 kg (39.7–46.1); p=0.004] and [45.0 kg (43.3–45.6) vs. 38.2 kg (35.1–42.6); p=0.004], respectively. There was moderate correlation (−0.42) between disease duration and muscle mass (MM), and weak (−0.38) between SARA (Scale for the Assessment and Rating of Ataxia) and MM in SCA3. In SCA10, there was no significant correlation between these variables. Female SCA3 patients had more body composition changes than female SCA10 patients, mainly in relation to FFM. SCA3 and SCA10 patients need nutritional follow-up to minimize body compartment changes.