Determination of the optimal acquisition protocol of breath-hold PET/CT for the diagnosis of thoracic lesions
Determination of the optimal acquisition protocol of breath-hold PET/CT for the diagnosis of thoracic lesions
复制标题
胸部病变诊断中屏气PET/CT最佳采集方案的确定
DOI：
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发表时间：
2011
影响因子：
1.5
通讯作者：
M. Sasaki
中科院分区：
文献类型：
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作者：
K. Mitsumoto;K. Abe;Y. Sakaguchi;T. Zhang;Yosuke Tachiya;Nobuyoshi Ohya;S. Baba;M. Sasaki
目的确定深吸气屏气（BH）氟-2-脱氧-d -葡萄糖正电子发射断层扫描（PET）检查胸部病变的最佳采集扫描方案。方法对21例患者32例胸部病变进行分析。每个床位进行全身PET/ CT自由呼吸扫描（FB） 3分钟，然后分别进行一次BH-CT和5次BH-PET扫描，各20秒。生成总采集时间分别为40、60、80和100 s的BH求和图像（分别为BH×2、BH×3、BH×4和BH×5）。根据每位患者的临床特征及h -PET图像的总和，评估PET与CT图像之间的位移、PET图像的病变体积、最大标准化摄取值（SUVmax）和PET图像质量。结果hb - pet能显著降低肿瘤体积（FB: 7.23±9.70 cm3, BH×5: 4.71±5.14 cm3， P<0.01），提高SUVmax （FB: 6.27±5.41,BH×5: 7.53±6.28，P<0.01）。在BH扫描中，PET与CT图像之间的位移明显改善（FB: 0.77±0.53 cm, BH×5: 0.36±0.24 cm， P<0.01）。此外，患者的年龄和肺功能也会影响hb - pet的重复性。将3张及以上的BH-PET图像相加（总采集时间在60s以上），得到了较好的图像质量。结论bh -PET/CT改善了PET与CT图像的错配，提高了胸部病变的SUVmax。在20秒的采集时间内，建议汇总的BH-PET图像数量为3张或更多。
ObjectiveThe aim of this study was to determine the optimal acquisition scan protocol for deep inspiration breath-hold (BH) fluoro-2-deoxy-D-glucose positron emission tomography (PET) for the examination of thoracic lesions. MethodsWe studied 32 thoracic lesions in 21 patients. Whole-body PET/computed tomography (CT) scanning with free breathing (FB) was performed for 3 min per bed position, followed by a BH-CT and five BH-PET for 20 s each. Summed BH images with total acquisition times of 40, 60, 80 and 100 s were generated (BH×2, BH×3, BH×4 and BH×5, respectively). The displacements between PET and CT images, the lesion volume of the PET image, the maximum standardized uptake value (SUVmax) and the quality of the PET image were assessed in relation to the clinical characteristics of each patient and the summation of the BH-PET images. ResultsBH-PET decreased the tumor volume significantly (FB: 7.23±9.70 cm3, BH×5: 4.71±5.14 cm3, P<0.01) and increased the SUVmax (FB: 6.27±5.41, BH×5: 7.53±6.28, P<0.01). The displacement between the PET and CT images was improved significantly in the BH scans (FB: 0.77±0.53 cm, BH×5: 0.36±0.24 cm, P<0.01). In addition, aging and lung function of patients influenced the reproducibility of BH-PET. The summed BH-PET images, obtained by summation of three or more BH-PET images (total acquisition time of 60 s or more), achieved good image quality. ConclusionBH-PET/CT improved the misregistration between PET and CT images and increased the SUVmax of thoracic lesions. The recommended number of BH-PET images for summation with 20 s of acquisition time is three or more.
DOI：
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发表时间：
1999-07
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
A. Chatziioannou;S. Cherry;Y. Shao;R. Silverman;K. Meadors;T. Farquhar;Marjan Pedarsani;M. Phelps
通讯作者：
A. Chatziioannou;S. Cherry;Y. Shao;R. Silverman;K. Meadors;T. Farquhar;Marjan Pedarsani;M. Phelps